Cell signalling: IP3 receptors channel calcium into cell death - PubMed (original) (raw)
Review
. 2004 Nov 9;14(21):R933-5.
doi: 10.1016/j.cub.2004.10.019.
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- PMID: 15530388
- DOI: 10.1016/j.cub.2004.10.019
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Review
Cell signalling: IP3 receptors channel calcium into cell death
C Jane Hanson et al. Curr Biol. 2004.
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Abstract
There is substantial evidence that Ca2+ fluxes occur during most forms of apoptosis, and that inhibiting such fluxes protects cells from death. IP3 receptors--ligand-gated channels that release Ca2+ from intracellular stores--are emerging as key sites for regulation by pro- and anti-apoptotic factors.
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