Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning - PubMed (original) (raw)

Comparative Study

. 2004 Nov-Dec;11(6):727-31.

doi: 10.1101/lm.83304. Epub 2004 Nov 10.

Affiliations

• PMID: 15537738
• DOI: 10.1101/lm.83304

Comparative Study

Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning

Lisa M Rattiner et al. Learn Mem. 2004 Nov-Dec.

Abstract

Brain-derived neurotrophic factor (BDNF) has been implicated as a molecular mediator of learning and memory. The BDNF gene contains four differentially regulated promoters that generate four distinct mRNA transcripts, each containing a unique noncoding 5'-exon and a common 3'-coding exon. This study describes novel evidence for the differential usage of alternative BDNF promoters and 5'-exons during the consolidation of learning. We found a selective increase in BDNF transcripts containing exons I and III in the amygdala 2 h following fear conditioning, while mRNA levels of BDNF exons II and IV remained unchanged. These results provide the first evidence of differential splicing and/or differential BDNF promoter usage in response to a behaviorally relevant learning paradigm.

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