The role of oxidative damage and stress in aging - PubMed (original) (raw)

Review

. 2004 Oct-Nov;125(10-11):811-26.

doi: 10.1016/j.mad.2004.07.009.

Affiliations

• PMID: 15541775
• DOI: 10.1016/j.mad.2004.07.009

Review

The role of oxidative damage and stress in aging

Alex Bokov et al. Mech Ageing Dev. 2004 Oct-Nov.

Abstract

The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various biomolecules increases with age, and caloric restriction, which increases life span and retards aging, reduces the age-related increase in oxidative damage to biomolecules. The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span. For the first time, investigators can use genetically altered animals to test directly the role of oxidative damage in aging. In this manuscript, we critically review the past research in this area and discuss potential future research directions in testing the Free Radical/Oxidative Theory of Aging.

PubMed Disclaimer

Similar articles

• Trends in oxidative aging theories.
  Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Muller FL, et al. Free Radic Biol Med. 2007 Aug 15;43(4):477-503. doi: 10.1016/j.freeradbiomed.2007.03.034. Epub 2007 Apr 10. Free Radic Biol Med. 2007. PMID: 17640558 Review.
• Age-related increase of reactive oxygen generation in the brains of mammals and birds: is reactive oxygen a signaling molecule to determine the aging process and life span?
  Sasaki T, Unno K, Tahara S, Kaneko T. Sasaki T, et al. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S10-24. doi: 10.1111/j.1447-0594.2010.00601.x. Geriatr Gerontol Int. 2010. PMID: 20590825
• Effects of fasting on oxidative stress in rat liver mitochondria.
  Sorensen M, Sanz A, Gómez J, Pamplona R, Portero-Otín M, Gredilla R, Barja G. Sorensen M, et al. Free Radic Res. 2006 Apr;40(4):339-47. doi: 10.1080/10715760500250182. Free Radic Res. 2006. PMID: 16517498
• Free radicals and brain aging.
  Poon HF, Calabrese V, Scapagnini G, Butterfield DA. Poon HF, et al. Clin Geriatr Med. 2004 May;20(2):329-59. doi: 10.1016/j.cger.2004.02.005. Clin Geriatr Med. 2004. PMID: 15182885 Review.
• [Ageing free radicals and cellular stress].
  Barouki R. Barouki R. Med Sci (Paris). 2006 Mar;22(3):266-72. doi: 10.1051/medsci/2006223266. Med Sci (Paris). 2006. PMID: 16527207 Review. French.

Cited by

• Resilience in Aging Mice.
  Kirkland JL, Stout MB, Sierra F. Kirkland JL, et al. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1407-1414. doi: 10.1093/gerona/glw086. Epub 2016 Aug 16. J Gerontol A Biol Sci Med Sci. 2016. PMID: 27535963 Free PMC article.
• The role of oxidative stress in nervous system aging.
  Sims-Robinson C, Hur J, Hayes JM, Dauch JR, Keller PJ, Brooks SV, Feldman EL. Sims-Robinson C, et al. PLoS One. 2013 Jul 2;8(7):e68011. doi: 10.1371/journal.pone.0068011. Print 2013. PLoS One. 2013. PMID: 23844146 Free PMC article.
• Salvia macilenta exhibits antiglycating activity and protects PC12 cells against H2O 2-induced apoptosis.
  Tusi SK, Khodagholi F. Tusi SK, et al. Cytotechnology. 2014 Jan;66(1):169-79. doi: 10.1007/s10616-013-9550-x. Epub 2013 Apr 12. Cytotechnology. 2014. PMID: 23579246 Free PMC article.
• Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.
  Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV. Nasto LA, et al. J Orthop Res. 2013 Jul;31(7):1150-7. doi: 10.1002/jor.22320. Epub 2013 Feb 6. J Orthop Res. 2013. PMID: 23389888 Free PMC article.
• Association of the OGG1 Ser326Cys polymorphism with tooth loss.
  Hasui Y, Hamanaka Y, Okayama N, Suehiro Y, Shinozaki F, Ueyama Y, Hinoda Y. Hasui Y, et al. J Clin Lab Anal. 2006;20(2):47-51. doi: 10.1002/jcla.20101. J Clin Lab Anal. 2006. PMID: 16538639 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • FlyBase

• Miscellaneous

  • NCI CPTAC Assay Portal