Support for involvement of neuregulin 1 in schizophrenia pathophysiology - PubMed (original) (raw)
Clinical Trial
. 2005 Apr;10(4):366-74, 328.
doi: 10.1038/sj.mp.4001608.
F A Middleton, A Kirby, K A Aldinger, S Purcell, A R Tahl, C P Morley, L McGann, K L Gentile, G N Rockwell, H M Medeiros, C Carvalho, A Macedo, A Dourado, J Valente, C P Ferreira, N J Patterson, M H Azevedo, M J Daly, C N Pato, M T Pato, P Sklar
Affiliations
- PMID: 15545978
- DOI: 10.1038/sj.mp.4001608
Clinical Trial
Support for involvement of neuregulin 1 in schizophrenia pathophysiology
T L Petryshen et al. Mol Psychiatry. 2005 Apr.
Abstract
Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We tested NRG1 markers and haplotypes for association in 111 parent-proband trios, 321 unrelated cases, and 242 control individuals. Associations were found with a haplotype that overlaps the risk haplotype originally reported in the Icelandic population ("Hap(ICE)"), and two haplotypes located in the 3' end of NRG1 (all P<0.05). However, association was not detected with Hap(ICE) itself. Comparison of NRG1 transcript expression in peripheral leukocytes from schizophrenia patients and unaffected siblings identified 3.8-fold higher levels of the SMDF variant in patients (P=0.039). Significant positive correlations (P<0.001) were found between SMDF and HRG-beta 2 expression and between HRG-gamma and ndf43 expression, suggesting common transcriptional regulation of NRG1 variants. In summary, our results suggest that haplotypes across NRG1 and multiple NRG1 variants are involved in schizophrenia.
Similar articles
- Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia.
Li D, Collier DA, He L. Li D, et al. Hum Mol Genet. 2006 Jun 15;15(12):1995-2002. doi: 10.1093/hmg/ddl122. Epub 2006 May 10. Hum Mol Genet. 2006. PMID: 16687441 - Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population.
Alaerts M, Ceulemans S, Forero D, Moens LN, De Zutter S, Heyrman L, Lenaerts AS, Norrback KF, De Rijk P, Nilsson LG, Goossens D, Adolfsson R, Del-Favero J. Alaerts M, et al. Arch Gen Psychiatry. 2009 Aug;66(8):828-37. doi: 10.1001/archgenpsychiatry.2009.82. Arch Gen Psychiatry. 2009. PMID: 19652122 - Association between the neuregulin 1 gene and schizophrenia: a systematic review.
Tosato S, Dazzan P, Collier D. Tosato S, et al. Schizophr Bull. 2005 Jul;31(3):613-7. doi: 10.1093/schbul/sbi043. Epub 2005 Aug 4. Schizophr Bull. 2005. PMID: 16081509 - Association of the NRG1 gene and schizophrenia: a meta-analysis.
Munafò MR, Thiselton DL, Clark TG, Flint J. Munafò MR, et al. Mol Psychiatry. 2006 Jun;11(6):539-46. doi: 10.1038/sj.mp.4001817. Mol Psychiatry. 2006. PMID: 16520822 Review. - Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology.
Harrison PJ, Law AJ. Harrison PJ, et al. Biol Psychiatry. 2006 Jul 15;60(2):132-40. doi: 10.1016/j.biopsych.2005.11.002. Epub 2006 Jan 25. Biol Psychiatry. 2006. PMID: 16442083 Review.
Cited by
- NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction mice.
Dong J, Chen W, Liu N, Chang S, Zhu W, Kang J. Dong J, et al. Cell Death Discov. 2022 Dec 2;8(1):476. doi: 10.1038/s41420-022-01271-3. Cell Death Discov. 2022. PMID: 36460658 Free PMC article. - Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.
Furuta S, Aleksic B, Nawa Y, Kimura H, Kushima I, Ishizuka K, Kato H, Toyama M, Arioka Y, Mori D, Morikawa M, Inada T, Ozaki N. Furuta S, et al. Nagoya J Med Sci. 2022 May;84(2):260-268. doi: 10.18999/nagjms.84.2.260. Nagoya J Med Sci. 2022. PMID: 35967956 Free PMC article. - Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats.
Nawwar DA, Zaki HF, Sayed RH. Nawwar DA, et al. Inflammopharmacology. 2022 Oct;30(5):1891-1907. doi: 10.1007/s10787-022-01031-w. Epub 2022 Jul 25. Inflammopharmacology. 2022. PMID: 35876932 Free PMC article. - Neuregulin-1/ErbB4 signaling modulates Plasmodium falciparum HRP2-induced damage to brain cortical organoids.
Harbuzariu A, Nti A, Harp KO, Cespedes JC, Driss A, Stiles JK. Harbuzariu A, et al. iScience. 2022 May 14;25(6):104407. doi: 10.1016/j.isci.2022.104407. eCollection 2022 Jun 17. iScience. 2022. PMID: 35663028 Free PMC article. - Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation.
Chen P, Jing H, Xiong M, Zhang Q, Lin D, Ren D, Wang S, Yin D, Chen Y, Zhou T, Li B, Fei E, Pan BX. Chen P, et al. Cell Death Dis. 2021 Apr 14;12(4):403. doi: 10.1038/s41419-021-03687-8. Cell Death Dis. 2021. PMID: 33854034 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous