No transcription-translation feedback in circadian rhythm of KaiC phosphorylation - PubMed (original) (raw)
. 2005 Jan 14;307(5707):251-4.
doi: 10.1126/science.1102540. Epub 2004 Nov 18.
Affiliations
- PMID: 15550625
- DOI: 10.1126/science.1102540
No transcription-translation feedback in circadian rhythm of KaiC phosphorylation
Jun Tomita et al. Science. 2005.
Abstract
An autoregulatory transcription-translation feedback loop is thought to be essential in generating circadian rhythms in any model organism. In the cyanobacterium Synechococcus elongatus, the essential clock protein KaiC is proposed to form this type of transcriptional negative feedback. Nevertheless, we demonstrate here temperature-compensated, robust circadian cycling of KaiC phosphorylation even without kaiBC messenger RNA accumulation under continuous dark conditions. This rhythm persisted in the presence of a transcription or translation inhibitor. Moreover, kinetic profiles in the ratio of KaiC autophosphorylation-dephosphorylation were also temperature compensated in vitro. Thus, the cyanobacterial clock can keep time independent of de novo transcription and translation processes.
Similar articles
- Regulation of circadian clock gene expression by phosphorylation states of KaiC in cyanobacteria.
Murayama Y, Oyama T, Kondo T. Murayama Y, et al. J Bacteriol. 2008 Mar;190(5):1691-8. doi: 10.1128/JB.01693-07. Epub 2007 Dec 28. J Bacteriol. 2008. PMID: 18165308 Free PMC article. - A mathematical model for the Kai-protein-based chemical oscillator and clock gene expression rhythms in cyanobacteria.
Miyoshi F, Nakayama Y, Kaizu K, Iwasaki H, Tomita M. Miyoshi F, et al. J Biol Rhythms. 2007 Feb;22(1):69-80. doi: 10.1177/0748730406295749. J Biol Rhythms. 2007. PMID: 17229926 - Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro.
Nakajima M, Imai K, Ito H, Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, Kondo T. Nakajima M, et al. Science. 2005 Apr 15;308(5720):414-5. doi: 10.1126/science.1108451. Science. 2005. PMID: 15831759 - A cyanobacterial circadian clock based on the Kai oscillator.
Kondo T. Kondo T. Cold Spring Harb Symp Quant Biol. 2007;72:47-55. doi: 10.1101/sqb.2007.72.029. Cold Spring Harb Symp Quant Biol. 2007. PMID: 18419262 Review. - A circadian timing mechanism in the cyanobacteria.
Williams SB. Williams SB. Adv Microb Physiol. 2007;52:229-96. doi: 10.1016/S0065-2911(06)52004-1. Adv Microb Physiol. 2007. PMID: 17027373 Review.
Cited by
- Nascent-Seq analysis of Drosophila cycling gene expression.
Rodriguez J, Tang CH, Khodor YL, Vodala S, Menet JS, Rosbash M. Rodriguez J, et al. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):E275-84. doi: 10.1073/pnas.1219969110. Epub 2013 Jan 7. Proc Natl Acad Sci U S A. 2013. PMID: 23297234 Free PMC article. - Dephosphorylation of the core clock protein KaiC in the cyanobacterial KaiABC circadian oscillator proceeds via an ATP synthase mechanism.
Egli M, Mori T, Pattanayek R, Xu Y, Qin X, Johnson CH. Egli M, et al. Biochemistry. 2012 Feb 28;51(8):1547-58. doi: 10.1021/bi201525n. Epub 2012 Feb 13. Biochemistry. 2012. PMID: 22304631 Free PMC article. - The BMAL1 C terminus regulates the circadian transcription feedback loop.
Kiyohara YB, Tagao S, Tamanini F, Morita A, Sugisawa Y, Yasuda M, Yamanaka I, Ueda HR, van der Horst GT, Kondo T, Yagita K. Kiyohara YB, et al. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10074-9. doi: 10.1073/pnas.0601416103. Epub 2006 Jun 15. Proc Natl Acad Sci U S A. 2006. PMID: 16777965 Free PMC article. - In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.
Lin JM, Schroeder A, Allada R. Lin JM, et al. J Neurosci. 2005 Nov 30;25(48):11175-83. doi: 10.1523/JNEUROSCI.2159-05.2005. J Neurosci. 2005. PMID: 16319317 Free PMC article. - An allosteric model of circadian KaiC phosphorylation.
van Zon JS, Lubensky DK, Altena PR, ten Wolde PR. van Zon JS, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7420-5. doi: 10.1073/pnas.0608665104. Epub 2007 Apr 25. Proc Natl Acad Sci U S A. 2007. PMID: 17460047 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources