Dog star rising: the canine genetic system - PubMed (original) (raw)
Review
doi: 10.1038/nrg1492.
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- PMID: 15573122
- DOI: 10.1038/nrg1492
Review
Dog star rising: the canine genetic system
Nathan B Sutter et al. Nat Rev Genet. 2004 Dec.
Abstract
Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds enriched for particular genetic disorders, the mapping and cloning of which have been facilitated by the availability of the canine genome map and sequence. These tools have aided our understanding of canine population genetics, linkage disequilibrium and haplotype sharing in the dog, and have informed ongoing efforts of the need to identify quantitative trait loci that are important in complex traits.
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