Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element - PubMed (original) (raw)
Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element
H Quesneville et al. Mol Biol Evol. 2005 Mar.
Erratum in
- Mol Biol Evol. 2005 Apr;22(4):1160
Abstract
The recently described THAP domain motif characterizes a DNA-binding domain (DBD) that is widely conserved in human and in animals. It presents a similarity with the DBD of the P element transposase of D. melanogaster. We show here that the P Drosophila neogenes derived from P-transposable elements conserve the THAP domain. Moreover, secondary rearrangements by exon shuffling indicate the recurrent recruitment of this domain by the host genome. As P sequences and THAP genes are found together in many animal genomes, we discuss the possibility that the THAP proteins have acquired their domain as a result of recurrent molecular domestication of P-transposable elements.
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