Reelin glycoprotein: structure, biology and roles in health and disease - PubMed (original) (raw)
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Reelin glycoprotein: structure, biology and roles in health and disease
S H Fatemi. Mol Psychiatry. 2005 Mar.
Abstract
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.
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