Fetal-type phosphorylation of the tau in paired helical filaments - PubMed (original) (raw)
Fetal-type phosphorylation of the tau in paired helical filaments
K Kanemaru et al. J Neurochem. 1992 May.
Abstract
To determine the phosphorylation sites of the tau in paired helical filaments (PHF), two types of PHF antisera with different specificities were used: One was a conventional anti-PHF, and the other was an antiserum to formic acid-denatured PHF (anti-HFoPHF). Phosphorylated tau-specific antibodies, anti-ptau 1 and anti-ptau 2, were prepared from anti-PHF and anti-HFoPHF, respectively. We found that both anti-ptau 1 and anti-ptau 2 labeled fetal or juvenile tau but not adult tau. The anti-ptau 1- and anti-ptau 2-recognition sites were immunochemically localized to the fragment Asp313 to Ile328 in the most COOH-terminal portion of tau. Furthermore, Ser315 was determined as the anti-ptau 2 recognition site. The sequence surrounding Ser315 was not found in the canonical sequences phosphorylated with known kinases.
Similar articles
- Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
Hoffmann R, Lee VM, Leight S, Varga I, Otvos L Jr. Hoffmann R, et al. Biochemistry. 1997 Jul 1;36(26):8114-24. doi: 10.1021/bi970380+. Biochemistry. 1997. PMID: 9201960 - Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau.
Yoshida H, Ihara Y. Yoshida H, et al. J Neurochem. 1993 Sep;61(3):1183-6. doi: 10.1111/j.1471-4159.1993.tb03642.x. J Neurochem. 1993. PMID: 8360683 - Posttranslational modifications of tau in paired helical filaments.
Morishima M, Ihara Y. Morishima M, et al. Dementia. 1994 Sep-Oct;5(5):282-8. doi: 10.1159/000106736. Dementia. 1994. PMID: 7951685 Review. - The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments.
Kenessey A, Yen SH. Kenessey A, et al. Brain Res. 1993 Nov 26;629(1):40-6. doi: 10.1016/0006-8993(93)90478-6. Brain Res. 1993. PMID: 8287279 - Hyperphosphorylation of tau in PHF.
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y. Morishima-Kawashima M, et al. Neurobiol Aging. 1995 May-Jun;16(3):365-71; discussion 371-80. doi: 10.1016/0197-4580(95)00027-c. Neurobiol Aging. 1995. PMID: 7566346 Review.
Cited by
- Insights into Disease-Associated Tau Impact on Mitochondria.
Szabo L, Eckert A, Grimm A. Szabo L, et al. Int J Mol Sci. 2020 Sep 1;21(17):6344. doi: 10.3390/ijms21176344. Int J Mol Sci. 2020. PMID: 32882957 Free PMC article. Review. - Biomarkers in Alzheimer's disease: past, present and future.
Gustaw-Rothenberg K, Lerner A, Bonda DJ, Lee HG, Zhu X, Perry G, Smith MA. Gustaw-Rothenberg K, et al. Biomark Med. 2010 Feb;4(1):15-26. doi: 10.2217/bmm.09.86. Biomark Med. 2010. PMID: 20387301 Free PMC article. Review. - Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.
Williamson R, Scales T, Clark BR, Gibb G, Reynolds CH, Kellie S, Bird IN, Varndell IM, Sheppard PW, Everall I, Anderton BH. Williamson R, et al. J Neurosci. 2002 Jan 1;22(1):10-20. doi: 10.1523/JNEUROSCI.22-01-00010.2002. J Neurosci. 2002. PMID: 11756483 Free PMC article. - Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics.
Iwatsubo T, Hasegawa M, Ihara Y. Iwatsubo T, et al. Acta Neuropathol. 1994;88(2):129-36. doi: 10.1007/BF00294505. Acta Neuropathol. 1994. PMID: 7985493 - Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.
Goedert M. Goedert M. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1101-18. doi: 10.1098/rstb.1999.0466. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434313 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources