Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin - PubMed (original) (raw)
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin
Louise Wickham et al. J Neurochem. 2005 Jan.
Free article
Abstract
Using a yeast two-hybrid system, we screened a human brain cDNA library for possible interacting proteins with the C-terminal cytosolic tail of the beta-secretase beta-amyloid protein converting enzyme (BACE)1. This identified seven potential candidates, including the brain-specific type II membrane protein BRI3. Co-localization and co-immunoprecipitation experiments confirmed that BACE1 and BRI3 co-localize and interact with each other via the cytosolic tail of BACE1. Furthermore, pulse and pulse-chase analyses revealed that the pro-protein convertases furin, and to a lesser extent PC7 and PC5A, process BRI3 into a C-terminal secreted approximately 4-kDa product. Thus, furin efficiently processes both pro-BACE1 and its novel interacting protein pro-BRI3.
Similar articles
- In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ. Sankaranarayanan S, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. doi: 10.1124/jpet.107.130039. Epub 2007 Dec 21. J Pharmacol Exp Ther. 2008. PMID: 18156464 - P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF. Meredith JE Jr, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22. J Pharmacol Exp Ther. 2008. PMID: 18499745 - The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG. Benjannet S, et al. Biochem Biophys Res Commun. 2004 Dec 3;325(1):235-42. doi: 10.1016/j.bbrc.2004.10.019. Biochem Biophys Res Commun. 2004. PMID: 15522224 - The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.
Stockley JH, O'Neill C. Stockley JH, et al. Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. doi: 10.1042/BST0350574. Biochem Soc Trans. 2007. PMID: 17511655 Review. - Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments.
Vetrivel KS, Thinakaran G. Vetrivel KS, et al. Neurology. 2006 Jan 24;66(2 Suppl 1):S69-73. doi: 10.1212/01.wnl.0000192107.17175.39. Neurology. 2006. PMID: 16432149 Review.
Cited by
- The Alzheimer's disease beta-secretase enzyme, BACE1.
Cole SL, Vassar R. Cole SL, et al. Mol Neurodegener. 2007 Nov 15;2:22. doi: 10.1186/1750-1326-2-22. Mol Neurodegener. 2007. PMID: 18005427 Free PMC article. - BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis.
Marks N, Berg MJ. Marks N, et al. Neurochem Res. 2010 Feb;35(2):181-210. doi: 10.1007/s11064-009-0054-1. Epub 2009 Sep 17. Neurochem Res. 2010. PMID: 19760173 Review. - β-Secretase: its biology as a therapeutic target in diseases.
Wang H, Li R, Shen Y. Wang H, et al. Trends Pharmacol Sci. 2013 Apr;34(4):215-25. doi: 10.1016/j.tips.2013.01.008. Epub 2013 Feb 27. Trends Pharmacol Sci. 2013. PMID: 23452816 Free PMC article. Review. - Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE. Lakshmana MK, et al. J Biol Chem. 2009 May 1;284(18):11863-72. doi: 10.1074/jbc.M807345200. Epub 2009 Feb 27. J Biol Chem. 2009. PMID: 19251705 Free PMC article. - Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System.
Buxbaum JN, Johansson J. Buxbaum JN, et al. Front Neurosci. 2017 Mar 15;11:119. doi: 10.3389/fnins.2017.00119. eCollection 2017. Front Neurosci. 2017. PMID: 28360830 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases