Chronic versus acute myelogenous leukemia: a question of self-renewal - PubMed (original) (raw)

Comparative Study

Chronic versus acute myelogenous leukemia: a question of self-renewal

Catriona H M Jamieson et al. Cancer Cell. 2004 Dec.

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Abstract

Leukemia stem cells are defined as transformed hematopoietic stem cells or committed progenitor cells that have amplified or acquired the stem cell capacity for self-renewal, albeit in a poorly regulated fashion. In this issue of Cancer Cell, Huntly and colleagues report a striking difference in the ability of two leukemia-associated fusion proteins, MOZ-TIF2 and BCR-ABL, to transform myeloid progenitor populations. This rigorous study supports the idea of a hierarchy among leukemia-associated protooncogenes for their ability to endow committed myeloid progenitors with the self-renewal capacity driving leukemic stem cell propagation, and sheds new light on the pathogenesis of chronic and acute myelogenous leukemias.

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• MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
  Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, Amaral S, Curley D, Williams IR, Akashi K, Gilliland DG. Huntly BJ, et al. Cancer Cell. 2004 Dec;6(6):587-96. doi: 10.1016/j.ccr.2004.10.015. Cancer Cell. 2004. PMID: 15607963

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