IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes - PubMed (original) (raw)
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Véronique Giudicelli et al. Nucleic Acids Res. 2005.
Abstract
IMGT/GENE-DB is the comprehensive IMGT genome database for immunoglobulin (IG) and T cell receptor (TR) genes from human and mouse, and, in development, from other vertebrates. IMGT/GENE-DB is the international reference for the IG and TR gene nomenclature and works in close collaboration with the HUGO Nomenclature Committee, Mouse Genome Database and genome committees for other species. IMGT/GENE-DB allows a search of IG and TR genes by locus, group and subgroup, which are CLASSIFICATION concepts of IMGT-ONTOLOGY. Short cuts allow the retrieval gene information by gene name or clone name. Direct links with configurable URL give access to information usable by humans or programs. An IMGT/GENE-DB entry displays accurate gene data related to genome (gene localization), allelic polymorphisms (number of alleles, IMGT reference sequences, functionality, etc.) gene expression (known cDNAs), proteins and structures (Protein displays, IMGT Colliers de Perles). It provides internal links to the IMGT sequence databases and to the IMGT Repertoire Web resources, and external links to genome and generalist sequence databases. IMGT/GENE-DB manages the IMGT reference directory used by the IMGT tools for IG and TR gene and allele comparison and assignment, and by the IMGT databases for gene data annotation. IMGT/GENE-DB is freely available at http://imgt.cines.fr.
Figures
Figure 1
The IMGT/GENE-DB Query page.
Figure 2
The IMGT/GENE-DB result page and the three types of choice in ‘Choose your display’.
Similar articles
- IMGT-ONTOLOGY for immunogenetics and immunoinformatics.
Lefranc MP, Giudicelli V, Ginestoux C, Bosc N, Folch G, Guiraudou D, Jabado-Michaloud J, Magris S, Scaviner D, Thouvenin V, Combres K, Girod D, Jeanjean S, Protat C, Yousfi-Monod M, Duprat E, Kaas Q, Pommié C, Chaume D, Lefranc G. Lefranc MP, et al. In Silico Biol. 2004;4(1):17-29. Epub 2003 Nov 22. In Silico Biol. 2004. PMID: 15089751 - IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics.
Lefranc MP, Giudicelli V, Ginestoux C, Chaume D. Lefranc MP, et al. Stud Health Technol Inform. 2003;95:74-9. Stud Health Technol Inform. 2003. PMID: 14663966 - IMGT, the international ImMunoGeneTics information system.
Lefranc MP, Giudicelli V, Kaas Q, Duprat E, Jabado-Michaloud J, Scaviner D, Ginestoux C, Clément O, Chaume D, Lefranc G. Lefranc MP, et al. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D593-7. doi: 10.1093/nar/gki065. Nucleic Acids Res. 2005. PMID: 15608269 Free PMC article. - IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr.
Lefranc MP. Lefranc MP. Leukemia. 2003 Jan;17(1):260-6. doi: 10.1038/sj.leu.2402637. Leukemia. 2003. PMID: 12529691 Review. - IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr.
Lefranc MP. Lefranc MP. Novartis Found Symp. 2003;254:126-36; discussion 136-42, 216-22, 250-2. Novartis Found Symp. 2003. PMID: 14712935 Review.
Cited by
- Inferring processes underlying B-cell repertoire diversity.
Elhanati Y, Sethna Z, Marcou Q, Callan CG Jr, Mora T, Walczak AM. Elhanati Y, et al. Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676):20140243. doi: 10.1098/rstb.2014.0243. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 26194757 Free PMC article. - A model for the evolution of the mammalian t-cell receptor α/δ and μ loci based on evidence from the duckbill Platypus.
Parra ZE, Lillie M, Miller RD. Parra ZE, et al. Mol Biol Evol. 2012 Oct;29(10):3205-14. doi: 10.1093/molbev/mss128. Epub 2012 May 15. Mol Biol Evol. 2012. PMID: 22593227 Free PMC article. - Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity.
Toshkova N, Zhelyzkova V, Reyes-Ruiz A, Haerens E, de Castro Deus M, Lacombe RV, Lecerf M, Gonzalez G, Jouvenet N, Planchais C, Dimitrov JD. Toshkova N, et al. Nat Commun. 2024 Jul 13;15(1):5878. doi: 10.1038/s41467-024-50316-x. Nat Commun. 2024. PMID: 38997292 Free PMC article. - Human transitional and IgMlow mature naïve B cells preserve permissive B-cell receptors.
Zhang Z, Jara CJ, Singh M, Xu H, Goodnow CC, Jackson KJ, Reed JH. Zhang Z, et al. Immunol Cell Biol. 2021 Sep;99(8):865-878. doi: 10.1111/imcb.12478. Epub 2021 Jun 4. Immunol Cell Biol. 2021. PMID: 33988890 Free PMC article. - Human germinal centres engage memory and naive B cells after influenza vaccination.
Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Alsoussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Richey ST, Haile A, Yang YR, Klebert MK, Suessen T, Teefey S, Presti RM, Krammer F, Kleinstein SH, Ward AB, Ellebedy AH. Turner JS, et al. Nature. 2020 Oct;586(7827):127-132. doi: 10.1038/s41586-020-2711-0. Epub 2020 Aug 31. Nature. 2020. PMID: 32866963 Free PMC article.
References
- Lefranc M.-P. (2003) IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia, 17, 260–266. - PubMed
- Lefranc M.-P. (2004) IMGT-ONTOLOGY and IMGT databases, tools and web resources for immunogenetics and immunoinformatics. Mol. Immunol., 40, 647–659. - PubMed
- Lefranc M.-P. (2003) IMGT, the international ImMunoGeneTics information system®, http://imgt.cines.fr. In Bock,G. and Goode,J. (eds), Immunoinformatics: Bioinformatics Strategies for Better Understanding of Immune Function. Novartis Foundation Symposium 254. John Wiley and Sons, Chichester, pp. 126–136, discussion pp. 136–142, 216–222, 250–252. - PubMed
- Lefranc M.-P., Giudicelli,V., Ginestoux,C., Bosc,N., Folch,G., Guiraudou,D., Jabado-Michaloud,J., Magris,S., Scaviner,D., Thouvenin,V., Combres,K., Girod,D., Jeanjean,S., Protat,C., Yousfi Monod,M., Duprat,E., Kaas,Q., Pommié,C., Chaume,D. and Lefranc,G. (2004) IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics (http://imgt.cines.fr). Epub In Silico Biology, 4, 0004. In Silico Biology, 4, 17–29. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous