Effects of endotoxin-associated protein on hematopoiesis - PubMed (original) (raw)

Effects of endotoxin-associated protein on hematopoiesis

R Porat et al. Infect Immun. 1992 May.

Abstract

Endotoxin-associated protein (EAP), a gram-negative bacterial cell wall component, was evaluated for its effects on hematopoietic colony formation in vitro. Colony-stimulating activity, induced by EAP on circulating and bone marrow progenitor cells, was found to be partially mediated by T cells and augmented by interleukin-3. The addition of anti-human interleukin-1 (IL-1) antibodies reduced EAP activity, suggesting that EAP may induce IL-1 production. However, EAP was shown to promote the growth of mature progenitor cells independently, unlike the effects of IL-1 on the hematopoietic system. These studies demonstrate that bacterial components other than lipopolysaccharide, such as EAP, may have hematopoietic activity.

PubMed Disclaimer

Similar articles

• Endotoxin-associated protein: interleukin-1-like activity on serum amyloid A synthesis and T-lymphocyte activation.
  Johns MA, Sipe JD, Melton LB, Strom TB, McCabe WR. Johns MA, et al. Infect Immun. 1988 Jun;56(6):1593-601. doi: 10.1128/iai.56.6.1593-1601.1988. Infect Immun. 1988. PMID: 3286501 Free PMC article.
• Endotoxin-associated protein: a potent stimulus for human granulocytopoietic activity which may be accessory cell independent.
  Bjornson BH, Agura E, Harvey JM, Johns M, Andrews RG, McCabe WR. Bjornson BH, et al. Infect Immun. 1988 Jun;56(6):1602-7. doi: 10.1128/iai.56.6.1602-1607.1988. Infect Immun. 1988. PMID: 2836311 Free PMC article.
• The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo.
  Quesniaux VF, Wehrli S, Steiner C, Joergensen J, Schuurman HJ, Herrman P, Schreier MH, Schuler W. Quesniaux VF, et al. Blood. 1994 Sep 1;84(5):1543-52. Blood. 1994. PMID: 7520778
• The in vitro and in vivo effects of stem cell factor on human hematopoiesis.
  Hoffman R, Tong J, Brandt J, Traycoff C, Bruno E, McGuire BW, Gordon MS, McNiece I, Srour EF. Hoffman R, et al. Stem Cells. 1993 Jul;11 Suppl 2:76-82. doi: 10.1002/stem.5530110813. Stem Cells. 1993. PMID: 7691331 Review.
• Hematopoietic activities of interleukin 1.
  Henney CS. Henney CS. Behring Inst Mitt. 1988 Aug;(83):165-9. Behring Inst Mitt. 1988. PMID: 3071334 Review.

Cited by

• Modulins: a new class of cytokine-inducing, pro-inflammatory bacterial virulence factor.
  Henderson B, Wilson M. Henderson B, et al. Inflamm Res. 1995 May;44(5):187-97. doi: 10.1007/BF01782257. Inflamm Res. 1995. PMID: 7655992 Review.
• Endotoxin neutralization as a biomonitor for inflammatory bowel disease.
  Champion K, Chiu L, Ferbas J, Pepe M. Champion K, et al. PLoS One. 2013 Jun 24;8(6):e67736. doi: 10.1371/journal.pone.0067736. Print 2013. PLoS One. 2013. PMID: 23826338 Free PMC article.
• Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis.
  Henderson B, Poole S, Wilson M. Henderson B, et al. Microbiol Rev. 1996 Jun;60(2):316-41. doi: 10.1128/mr.60.2.316-341.1996. Microbiol Rev. 1996. PMID: 8801436 Free PMC article. Review.
• Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum.
  Hellman J, Loiselle PM, Tehan MM, Allaire JE, Boyle LA, Kurnick JT, Andrews DM, Sik Kim K, Warren HS. Hellman J, et al. Infect Immun. 2000 May;68(5):2566-72. doi: 10.1128/IAI.68.5.2566-2572.2000. Infect Immun. 2000. PMID: 10768945 Free PMC article.

References

1. 1. Am J Pathol. 1978 Nov;93(2):526-618 - PubMed
2. 1. N Engl J Med. 1988 Jun 9;318(23):1481-6 - PubMed
3. 1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 - PubMed
4. 1. Lancet. 1990 Sep 22;336(8717):712-4 - PubMed
5. 1. J Immunol. 1988 Apr 1;140(7):2260-6 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central