Embryonic beginnings of adult hematopoietic stem cells - PubMed (original) (raw)
Affiliations
- PMID: 15642676
Review
Embryonic beginnings of adult hematopoietic stem cells
Charles Durand et al. Haematologica. 2005 Jan.
Abstract
Hematopoietic stem cells (HSC) are at the foundation of the adult hematopoietic system. HSC give rise to all blood cells through a complex series of proliferation and differentiation events that occur throughout the lifespan of the individual. Because of their clinical importance in transplantation protocols, recent research has focused on the developmental origins and potential of embryonic HSC. In both mammalian and non-mammalian vertebrate embryos, two independent anatomical sites have been found to generate hematopoietic cells. The yolk sac (or its equivalent in amphibians, the ventral blood islands) participates in a first transient wave of hematopoiesis by producing primitive erythrocytes. Importantly, adult-type HSCs emerge autonomously in a second wave of hematopoietic generation in an intraembryonic region surrounding the dorsal aorta, the aorta-gonads-mesonephros (AGM) region. In this review, we will discuss research advances in the field of developmental hematopoiesis, with a particular emphasis on the cellular origins of AGM HSC and their regulation by the embryonic hematopoietic microenvironment.
Similar articles
- Embryonic origin of human hematopoiesis.
Tavian M, Biasch K, Sinka L, Vallet J, Péault B. Tavian M, et al. Int J Dev Biol. 2010;54(6-7):1061-5. doi: 10.1387/ijdb.103097mt. Int J Dev Biol. 2010. PMID: 20711983 Review. - Expansive effects of aorta-gonad-mesonephros-derived stromal cells on hematopoietic stem cells from embryonic stem cells.
Fu JR, Liu WL, Zhou YF, Zhou JF, Sun HY, Luo L, Zhang H, Xu HZ. Fu JR, et al. Chin Med J (Engl). 2005 Dec 5;118(23):1979-86. Chin Med J (Engl). 2005. PMID: 16336834 - Cell-cell contact and anatomical compatibility in stromal cell-mediated HSC support during development.
Harvey K, Dzierzak E. Harvey K, et al. Stem Cells. 2004;22(3):253-8. doi: 10.1634/stemcells.22-3-253. Stem Cells. 2004. PMID: 15153602 - Stromal cell lines from the aorta-gonado-mesonephros region are potent supporters of murine and human hematopoiesis.
Weisel KC, Gao Y, Shieh JH, Moore MA. Weisel KC, et al. Exp Hematol. 2006 Nov;34(11):1505-16. doi: 10.1016/j.exphem.2006.06.013. Exp Hematol. 2006. PMID: 17046570 - Epiblast-derived stem cells in embryonic and adult tissues.
De Miguel MP, Arnalich Montiel F, Lopez Iglesias P, Blazquez Martinez A, Nistal M. De Miguel MP, et al. Int J Dev Biol. 2009;53(8-10):1529-40. doi: 10.1387/ijdb.072413md. Int J Dev Biol. 2009. PMID: 19757397 Review.
Cited by
- Intrinsic and Extrinsic Regulation of Hematopoiesis in Drosophila.
Koranteng F, Cho B, Shim J. Koranteng F, et al. Mol Cells. 2022 Mar 31;45(3):101-108. doi: 10.14348/molcells.2022.2039. Mol Cells. 2022. PMID: 35253654 Free PMC article. Review. - Chasing Mavericks: The quest for defining developmental waves of hematopoiesis.
Cool T, Forsberg EC. Cool T, et al. Curr Top Dev Biol. 2019;132:1-29. doi: 10.1016/bs.ctdb.2019.01.001. Epub 2019 Feb 6. Curr Top Dev Biol. 2019. PMID: 30797507 Free PMC article. Review. - LMO2 at 25 years: a paradigm of chromosomal translocation proteins.
Chambers J, Rabbitts TH. Chambers J, et al. Open Biol. 2015 Jun;5(6):150062. doi: 10.1098/rsob.150062. Open Biol. 2015. PMID: 26108219 Free PMC article. Review. - Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche.
Balmer GM, Riley PR. Balmer GM, et al. J Cardiovasc Transl Res. 2012 Oct;5(5):631-40. doi: 10.1007/s12265-012-9386-3. Epub 2012 Jun 15. J Cardiovasc Transl Res. 2012. PMID: 22700450 Review. - A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.
Burns CE, Galloway JL, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. Burns CE, et al. Blood. 2009 Jun 4;113(23):5776-82. doi: 10.1182/blood-2008-12-193607. Epub 2009 Mar 30. Blood. 2009. PMID: 19332767 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical