FoxM1 is required for execution of the mitotic programme and chromosome stability - PubMed (original) (raw)

doi: 10.1038/ncb1217. Epub 2005 Jan 16.

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• PMID: 15654331
• DOI: 10.1038/ncb1217

FoxM1 is required for execution of the mitotic programme and chromosome stability

Jamila Laoukili et al. Nat Cell Biol. 2005 Feb.

Abstract

Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.

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Comment in

• FoxM1 dances with mitosis.
  Costa RH. Costa RH. Nat Cell Biol. 2005 Feb;7(2):108-10. doi: 10.1038/ncb0205-108. Nat Cell Biol. 2005. PMID: 15689977 No abstract available.

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