Evaluation of humoral responsiveness in children - PubMed (original) (raw)

Affiliations

• PMID: 1565555

Review

Evaluation of humoral responsiveness in children

J G Wheeler et al. Pediatr Infect Dis J. 1992 Apr.

Abstract

The evaluation of postvaccine antibody responses can provide a reasonably convenient and useful adjunct to the evaluation of possible humoral immune dysfunction syndromes. In patients whose clinical history is suspicious for an antibody deficiency syndrome, such studies can document normal antibody responsiveness. On the other hand the wide age-dependent variation in antibody responses makes careful interpretation necessary in concluding that a patient falls outside the "normal" pattern of antibody responsiveness. Finding a patient well below the mean values for age for multiple vaccines in concert with an appropriate clinical history would strongly suggest an abnormality of immune regulation. At this time the finding of abnormal antibody responses does not always imply that intervention with immunoglobulin therapy is indicated or that it would lead to improvement in clinical symptoms. It might help justify prophylactic antibiotic programs, however, similar to those used for recurrent otitis media. Interpretation of antibody responses in children younger than 2 years of age is probably hazardous since many patients may have relative retardation in their normal development of polysaccharide antibody responsiveness. Such patients usually develop a normal response as they grow older and do not need long term therapy. Until new technologies for measuring immune competence are developed, the above-mentioned measures of humoral immunity, when combined with clinical judgment, should be adequate to guide clinical decision-making in most cases.

PubMed Disclaimer

Similar articles

• Clinical practice guideline: Otitis media with effusion.
  Rosenfeld RM, Culpepper L, Doyle KJ, Grundfast KM, Hoberman A, Kenna MA, Lieberthal AS, Mahoney M, Wahl RA, Woods CR Jr, Yawn B; American Academy of Pediatrics Subcommittee on Otitis Media with Effusion; American Academy of Family Physicians; American Academy of Otolaryngology--Head and Neck Surgery. Rosenfeld RM, et al. Otolaryngol Head Neck Surg. 2004 May;130(5 Suppl):S95-118. doi: 10.1016/j.otohns.2004.02.002. Otolaryngol Head Neck Surg. 2004. PMID: 15138413
• Anti-capsular polysaccharide antibody deficiency states.
  Rijkers GT, Sanders LA, Zegers BJ. Rijkers GT, et al. Immunodeficiency. 1993;5(1):1-21. Immunodeficiency. 1993. PMID: 8167745 Review.
• The clinical syndrome of specific antibody deficiency in children.
  Boyle RJ, Le C, Balloch A, Tang ML. Boyle RJ, et al. Clin Exp Immunol. 2006 Dec;146(3):486-92. doi: 10.1111/j.1365-2249.2006.03242.x. Clin Exp Immunol. 2006. PMID: 17100769 Free PMC article.
• [Immune response to different vaccines].
  Bégué P. Bégué P. Arch Pediatr. 1998;5 Suppl 2:182s-187s. Arch Pediatr. 1998. PMID: 9841084 Review. French. No abstract available.

Cited by

• Comparison of the AllplexTM Respiratory Panel Assays and the automated Fast Track Diagnostics Respiratory pathogens 21 assay for the diagnosis of pediatric respiratory viral infections.
  Concato C, Piccioni L, Ranno S, Antonelli F, Buonomini A, Coltella L, Pizzichemi G, Chiavelli S, Riva E. Concato C, et al. Arch Virol. 2020 May;165(5):1191-1196. doi: 10.1007/s00705-020-04593-8. Epub 2020 Mar 30. Arch Virol. 2020. PMID: 32232675 Free PMC article.
• Antibody deficiency associated with gold treatment: natural history and management in 22 patients.
  Snowden N, Dietch DM, Teh LS, Hilton RC, Haeney MR. Snowden N, et al. Ann Rheum Dis. 1996 Sep;55(9):616-21. doi: 10.1136/ard.55.9.616. Ann Rheum Dis. 1996. PMID: 8882131 Free PMC article.
• Percentile ranges for serum IgG subclass concentrations in healthy Chinese children.
  Lau YL, Jones BM, Ng KW, Yeung CY. Lau YL, et al. Clin Exp Immunol. 1993 Feb;91(2):337-41. doi: 10.1111/j.1365-2249.1993.tb05905.x. Clin Exp Immunol. 1993. PMID: 8428400 Free PMC article.
• The acquisition of anti-pneumococcal capsular polysaccharide Haemophilus influenzae type b and tetanus toxoid antibodies, with age, in the UK.
  Hazlewood M, Nusrat R, Kumararatne DS, Goodall M, Raykundalia C, Wang DG, Joyce HJ, Milford-Ward A, Forte M, Pahor A. Hazlewood M, et al. Clin Exp Immunol. 1993 Aug;93(2):157-64. doi: 10.1111/j.1365-2249.1993.tb07959.x. Clin Exp Immunol. 1993. PMID: 8348740 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information