Protein structural transitions and their functional role - PubMed (original) (raw)
Review
. 2005 Feb 15;363(1827):331-55; discussion 355-6.
doi: 10.1098/rsta.2004.1496.
Affiliations
- PMID: 15664887
- DOI: 10.1098/rsta.2004.1496
Review
Protein structural transitions and their functional role
Martin Karplus et al. Philos Trans A Math Phys Eng Sci. 2005.
Abstract
Living cells are a collection of molecular machines which carry out many of the functions essential for the cell's existence, differentiation and reproduction. Most, though not all, of these machines are made up of proteins. Because of their complexity, an understanding of how they work requires a synergistic combination of experimental and theoretical studies. In this paper we outline our studies of two such protein machines. One is GroEL, the chaperone from Escherichia coli, which aids in protein folding; the other is F(1)-ATPase, a motor protein which synthesizes and hydrolyses ATP.
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