Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R - PubMed (original) (raw)

Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R

M Vey et al. Virology. 1992 May.

Abstract

The hemagglutinin of influenza virus A/FPV/Rostock/34 (H7) was altered at its multibasic cleavage site by site-directed mutagenesis and assayed for proteolytic activation after expression in CV-1 cells. The results indicated that the cellular protease responsible for activation recognizes the tetrapeptide motif R-X-K/R-R that must be presented in the correct sequence position. Studies on plaque variants of influenza virus A/fowl/Victoria/75 (H7N7) showed that alteration of the consensus sequence resulted in a loss of pathogenicity for chickens.

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References

    1. Klenk H.-D., Rott R. In: Maramorosch K., Murphy F.A., Shatkin A.J., editors. Vol. 34. Academic Press; NY: 1988. pp. 247–281. (Advances in Virus Research).
    1. Lazarowitz S.G., Choppin P.W. Virology. 1975;68:440–454. - PubMed
    1. Gotoh B., Ogasawara T., Toyoda T., Inocencio N.M., Hamaguchi M., Nagai Y. EMBO J. 1990;9:4189–4195. - PMC - PubMed
    1. Tashiro M., Ciborowski P., Klenk H.-D., Pulverer G., Rott R. Nature. 1987;325:536–537. - PubMed
    1. Klenk H.-D., Garten W., Rott R. EMBO J. 1984;3:2911–2915. - PMC - PubMed

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