Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease - PubMed (original) (raw)
Meta-Analysis
. 2005 Feb 28;375(2):112-6.
doi: 10.1016/j.neulet.2004.10.078. Epub 2004 Nov 23.
Affiliations
- PMID: 15670652
- DOI: 10.1016/j.neulet.2004.10.078
Meta-Analysis
Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease
George D Mellick et al. Neurosci Lett. 2005.
Abstract
It remains unclear whether genetic variants in SNCA (the alpha-synuclein gene) alter risk for sporadic Parkinson's disease (PD). The polymorphic mixed sequence repeat (NACP-Rep1) in the promoter region of SNCA has been previously examined as a potential susceptibility factor for PD with conflicting results. We report genotype and allele distributions at this locus from 369 PD cases and 370 control subjects of European Australian ancestry, with alleles designated as -1, 0, +1, +2, and +3 as previously described. Allele frequencies designated (0) were less common in Australian cases compared to controls (OR=0.80, 95% CI 0.62-1.03). Combined analysis including all previously published ancestral European Rep1 data yielded a highly significant association between the 0 allele and a reduced risk for PD (OR=0.79, 95% CI 0.70-0.89, p=0.0001). Further study must now proceed to examine in detail this interesting and biologically plausible genetic association.
Similar articles
- Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.
Myhre R, Toft M, Kachergus J, Hulihan MM, Aasly JO, Klungland H, Farrer MJ. Myhre R, et al. Acta Neurol Scand. 2008 Nov;118(5):320-7. doi: 10.1111/j.1600-0404.2008.01019.x. Epub 2008 May 15. Acta Neurol Scand. 2008. PMID: 18485051 - Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Hadjigeorgiou GM, Xiromerisiou G, Gourbali V, Aggelakis K, Scarmeas N, Papadimitriou A, Singleton A. Hadjigeorgiou GM, et al. Mov Disord. 2006 Apr;21(4):534-9. doi: 10.1002/mds.20752. Mov Disord. 2006. PMID: 16250025 - [The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility].
Zhao XP, Zheng HM, Xie HJ, Ding SJ, Ren DM. Zhao XP, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Aug;21(4):339-41. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004. PMID: 15300629 Chinese. - Gene dosage and pathogenesis of Parkinson's disease.
Eriksen JL, Przedborski S, Petrucelli L. Eriksen JL, et al. Trends Mol Med. 2005 Mar;11(3):91-6. doi: 10.1016/j.molmed.2005.01.001. Trends Mol Med. 2005. PMID: 15760766 Review. - [Parkinson disease: monogenic forms and genetic susceptibility factors].
Brice A. Brice A. Pathol Biol (Paris). 1998 Nov;46(9):710-2. Pathol Biol (Paris). 1998. PMID: 9885826 Review. French.
Cited by
- α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.
Ritz B, Rhodes SL, Bordelon Y, Bronstein J. Ritz B, et al. PLoS One. 2012;7(5):e36199. doi: 10.1371/journal.pone.0036199. Epub 2012 May 15. PLoS One. 2012. PMID: 22615757 Free PMC article. - Key issues in essential tremor genetics research: Where are we now and how can we move forward?
Testa CM. Testa CM. Tremor Other Hyperkinet Mov (N Y). 2013;3:tre-03-105-1843-1. doi: 10.7916/D8Q23Z0Z. Epub 2013 Jan 22. Tremor Other Hyperkinet Mov (N Y). 2013. PMID: 23450143 Free PMC article. - Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.
Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H. Hu Y, et al. J Neurol. 2012 Mar;259(3):497-504. doi: 10.1007/s00415-011-6209-4. Epub 2011 Aug 19. J Neurol. 2012. PMID: 21853288 - The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis.
Zintzaras E, Hadjigeorgiou GM. Zintzaras E, et al. J Hum Genet. 2005;50(11):560-566. doi: 10.1007/s10038-005-0295-z. Epub 2005 Sep 20. J Hum Genet. 2005. PMID: 16172806 - Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells.
Ko LW, Ko HH, Lin WL, Kulathingal JG, Yen SH. Ko LW, et al. J Neuropathol Exp Neurol. 2008 Nov;67(11):1084-96. doi: 10.1097/NEN.0b013e31818c3618. J Neuropathol Exp Neurol. 2008. PMID: 18957893 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous