The cutaneous serotoninergic/melatoninergic system: securing a place under the sun - PubMed (original) (raw)
Review
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
Andrzej Slominski et al. FASEB J. 2005 Feb.
Abstract
It was recently discovered that mammalian skin can produce serotonin and transform it into melatonin. Pathways for the biosynthesis and biodegradation of serotonin and melatonin have been characterized in human and rodent skin and in their major cellular populations. Moreover, receptors for serotonin and melatonin receptors are expressed in keratinocytes, melanocytes, and fibroblasts and these mediate phenotypic actions on cellular proliferation and differentiation. Melatonin exerts receptor-independent effects, including activation of pathways protective of oxidative stress and the modification of cellular metabolism. While serotonin is known to have several roles in skin-e.g., pro-edema, vasodilatory, proinflammatory, and pruritogenic-melatonin has been experimentally implicated in hair growth cycling, pigmentation physiology, and melanoma control. Thus, the widespread expression of a cutaneous seorotoninergic/melatoninergic syste,m(s) indicates considerable selectivity of action to facilitate intra-, auto-, or paracrine mechanisms that define and influence skin function in a highly compartmentalized manner. Notably, the cutaneous melatoninergic system is organized to respond to continuous stimulation in contrast to the pineal gland, which (being insulated from the external environment) responds to discontinuous activation by the circadian clock. Overall, the cutaneous serotoninergic/melatoninergic system could counteract or buffer external (environmental) or internal stresses to preserve the biological integrity of the organ and to maintain its homeostasis.-Slominski, A. J., Wortsman, J., Tobin, D. J. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun.
Similar articles
- Functional activity of serotoninergic and melatoninergic systems expressed in the skin.
Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. Slominski A, et al. J Cell Physiol. 2003 Jul;196(1):144-53. doi: 10.1002/jcp.10287. J Cell Physiol. 2003. PMID: 12767050 - Melatonin in the skin: synthesis, metabolism and functions.
Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Slominski A, et al. Trends Endocrinol Metab. 2008 Jan;19(1):17-24. doi: 10.1016/j.tem.2007.10.007. Epub 2007 Dec 26. Trends Endocrinol Metab. 2008. PMID: 18155917 Review. - Serotoninergic and melatoninergic systems are fully expressed in human skin.
Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, Slugocki G, McNulty J, Kauser S, Tobin DJ, Jing C, Johansson O. Slominski A, et al. FASEB J. 2002 Jun;16(8):896-8. doi: 10.1096/fj.01-0952fje. Epub 2002 Apr 23. FASEB J. 2002. PMID: 12039872 - On the role of melatonin in skin physiology and pathology.
Slominski A, Fischer TW, Zmijewski MA, Wortsman J, Semak I, Zbytek B, Slominski RM, Tobin DJ. Slominski A, et al. Endocrine. 2005 Jul;27(2):137-48. doi: 10.1385/ENDO:27:2:137. Endocrine. 2005. PMID: 16217127 Free PMC article. Review. - Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair.
Fischer TW, Slominski A, Zmijewski MA, Reiter RJ, Paus R. Fischer TW, et al. Exp Dermatol. 2008 Sep;17(9):713-30. doi: 10.1111/j.1600-0625.2008.00767.x. Epub 2008 Jul 17. Exp Dermatol. 2008. PMID: 18643846 Review.
Cited by
- Neuroendocrine Factors in Melanoma Pathogenesis.
Scheau C, Draghici C, Ilie MA, Lupu M, Solomon I, Tampa M, Georgescu SR, Caruntu A, Constantin C, Neagu M, Caruntu C. Scheau C, et al. Cancers (Basel). 2021 May 10;13(9):2277. doi: 10.3390/cancers13092277. Cancers (Basel). 2021. PMID: 34068618 Free PMC article. Review. - Differential expression of HPA axis homolog in the skin.
Slominski A, Wortsman J, Tuckey RC, Paus R. Slominski A, et al. Mol Cell Endocrinol. 2007 Feb;265-266:143-9. doi: 10.1016/j.mce.2006.12.012. Epub 2006 Dec 29. Mol Cell Endocrinol. 2007. PMID: 17197073 Free PMC article. Review. - Vertebrate melanophores as potential model for drug discovery and development: a review.
Salim S, Ali SA. Salim S, et al. Cell Mol Biol Lett. 2011 Mar;16(1):162-200. doi: 10.2478/s11658-010-0044-y. Epub 2010 Dec 27. Cell Mol Biol Lett. 2011. PMID: 21225472 Free PMC article. Review. - Sunshine, serotonin, and skin: a partial explanation for seasonal patterns in psychopathology?
Sansone RA, Sansone LA. Sansone RA, et al. Innov Clin Neurosci. 2013 Jul;10(7-8):20-4. Innov Clin Neurosci. 2013. PMID: 24062970 Free PMC article. - 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress.
Wu HL, Pang SL, Liu QZ, Wang Q, Cai MX, Shang J. Wu HL, et al. PLoS One. 2014 Feb 21;9(2):e89663. doi: 10.1371/journal.pone.0089663. eCollection 2014. PLoS One. 2014. PMID: 24586946 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources