Crossing the line between activation and repression - PubMed (original) (raw)
Crossing the line between activation and repression
Jun Ma. Trends Genet. 2005 Jan.
Abstract
Gene transcription can be activated or repressed. Such seemingly simple decisions reflect the coordinated actions of a wide array of proteins. Activators and co-activators work together to stimulate the assembly and activity of the machinery that transcribes the gene, whereas repressors and co-repressors work to achieve the opposite goal. Recent studies show that many proteins often engage in regulatory activities and interactions that cross the activation-repression divide. This article discusses selected examples to illustrate the dynamic nature of the transcriptional regulation process and highlights the important roles of not only the individual proteins but also their communication system.
Similar articles
- Biological activity of mammalian transcriptional repressors.
Thiel G, Lietz M, Bach K, Guethlein L, Cibelli G. Thiel G, et al. Biol Chem. 2001 Jun;382(6):891-902. doi: 10.1515/BC.2001.111. Biol Chem. 2001. PMID: 11501753 - Mechanisms of transcriptional activation and repression can both involve TFIID.
Manley JL, Um M, Li C, Ashali H. Manley JL, et al. Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29;351(1339):517-26. doi: 10.1098/rstb.1996.0050. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8735274 Review. - Biochemical mechanisms of gene regulation by polycomb group protein complexes.
Müller J, Verrijzer P. Müller J, et al. Curr Opin Genet Dev. 2009 Apr;19(2):150-8. doi: 10.1016/j.gde.2009.03.001. Epub 2009 Apr 1. Curr Opin Genet Dev. 2009. PMID: 19345089 Review. - Regulation of the p53 transcriptional activity.
Liu G, Chen X. Liu G, et al. J Cell Biochem. 2006 Feb 15;97(3):448-58. doi: 10.1002/jcb.20700. J Cell Biochem. 2006. PMID: 16288459 Review. - Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).
Berrevoets CA, Umar A, Trapman J, Brinkmann AO. Berrevoets CA, et al. Biochem J. 2004 May 1;379(Pt 3):731-8. doi: 10.1042/BJ20031456. Biochem J. 2004. PMID: 14744261 Free PMC article.
Cited by
- Potential biomarkers in Japanese encephalitis from different hosts and geographical locations.
Ziaullah M S, Azhar Kamal M, Khan Warsi M, Alghamdi S, Al Qahtani MY, Al Rumaihi AM, Akber AH, Al Qahtani MA, M Rafeeq M. Ziaullah M S, et al. Bioinformation. 2023 May 31;19(5):611-622. doi: 10.6026/97320630019611. eCollection 2023. Bioinformation. 2023. PMID: 37886150 Free PMC article. - Large-scale mapping and mutagenesis of human transcriptional effector domains.
DelRosso N, Tycko J, Suzuki P, Andrews C, Aradhana, Mukund A, Liongson I, Ludwig C, Spees K, Fordyce P, Bassik MC, Bintu L. DelRosso N, et al. Nature. 2023 Apr;616(7956):365-372. doi: 10.1038/s41586-023-05906-y. Epub 2023 Apr 5. Nature. 2023. PMID: 37020022 Free PMC article. - MYB Transcription Factor161 Mediates Feedback Regulation of Secondary wall-associated NAC-Domain1 Family Genes for Wood Formation.
Wang Z, Mao Y, Guo Y, Gao J, Liu X, Li S, Lin YJ, Chen H, Wang JP, Chiang VL, Li W. Wang Z, et al. Plant Physiol. 2020 Nov;184(3):1389-1406. doi: 10.1104/pp.20.01033. Epub 2020 Sep 17. Plant Physiol. 2020. PMID: 32943464 Free PMC article. - Active DNA demethylation regulates tracheary element differentiation in Arabidopsis.
Lin W, Sun L, Huang RZ, Liang W, Liu X, He H, Fukuda H, He XQ, Qian W. Lin W, et al. Sci Adv. 2020 Jun 26;6(26):eaaz2963. doi: 10.1126/sciadv.aaz2963. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32637594 Free PMC article. - Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/β-Catenin Signaling in WiT49 Cells.
Li Y, Gong H, Ding J, Zhao F, Du J, Wan J, Zhang J, Liu S, Li J, Wang L, Zhou B. Li Y, et al. Front Cell Dev Biol. 2020 Mar 17;8:94. doi: 10.3389/fcell.2020.00094. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32258025 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases