Chromosomal instability in flat adenomas and carcinomas of the colon - PubMed (original) (raw)

. 2005 Mar;205(4):514-21.

doi: 10.1002/path.1733.

Affiliations

• PMID: 15685687
• DOI: 10.1002/path.1733

Chromosomal instability in flat adenomas and carcinomas of the colon

C Postma et al. J Pathol. 2005 Mar.

Abstract

Flat adenomas are flat or slightly elevated dysplastic lesions of the colorectal mucosa, mostly with a tubular architecture. Compared with polypoid adenomas of similar size, flat adenomas show a higher frequency of high-grade dysplasia and rapid submucosal invasion. The aim of this study was to survey whether flat colorectal lesions differ in their pattern of chromosomal aberrations from their polypoid counterparts. Six flat adenomas and 12 flat carcinomas were analysed by comparative genomic hybridization (CGH) and the pattern of chromosomal aberrations was compared with a previously published series of 112 polypoid adenomas and 82 polypoid carcinomas. In addition, multiplex ligation-dependent probe amplification (MLPA) for identifying DNA copy number changes of 25 individual genes on chromosome 20 was performed on 14 flat and 15 polypoid tumours. With CGH, flat adenomas showed on average 1.8 gains (range 1-4) and 3.2 losses (range 0-4), and the flat carcinomas 4.5 gains (range 0-8) and 3.5 losses (range 1-6). In both adenomas and carcinomas, high frequencies of 20q gain (83% and 92%, respectively) and 18q loss (83% and 92%, respectively) were found. This correlation between 20q gain and 18q loss had previously been observed in a subgroup of polypoid colorectal tumours. Both flat and polypoid colorectal tumours with 20q gains by CGH showed similar patterns of copy number ratios for the individual genes tested. TOP1, BCL2L1, and E2F1 had median copy number ratios of 2 or higher, while ZNF217 had a ratio around 3. In conclusion, flat adenomas and carcinomas of the large intestine show a similar pattern of chromosomal aberrations to that observed in a specific subgroup of polypoid lesions. The transcription factor ZNF217 is an important candidate for driving the 20q gain.

PubMed Disclaimer

Similar articles

• Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes.
  De Angelis PM, Clausen OP, Schjølberg A, Stokke T. De Angelis PM, et al. Br J Cancer. 1999 May;80(3-4):526-35. doi: 10.1038/sj.bjc.6690388. Br J Cancer. 1999. PMID: 10408863 Free PMC article.
• Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes.
  Castro P, Eknaes M, Teixeira MR, Danielsen HE, Soares P, Lothe RA, Sobrinho-Simões M. Castro P, et al. J Pathol. 2005 Jul;206(3):305-11. doi: 10.1002/path.1772. J Pathol. 2005. PMID: 15852498
• Distinct chromosomal imbalances in nonpolypoid and polypoid colorectal adenomas indicate different genetic pathways in the development of colorectal neoplasms.
  Richter H, Slezak P, Walch A, Werner M, Braselmann H, Jaramillo E, Ost A, Hirata I, Takahama K, Zitzelsberger H. Richter H, et al. Am J Pathol. 2003 Jul;163(1):287-94. doi: 10.1016/S0002-9440(10)63652-8. Am J Pathol. 2003. PMID: 12819033 Free PMC article.
• [Precancerous lesion in colorectal cancer].
  Nagawa H, Yamagata S, Muto T. Nagawa H, et al. Gan To Kagaku Ryoho. 1995 Dec;22(14):2043-7. Gan To Kagaku Ryoho. 1995. PMID: 8607613 Review. Japanese.
• Chromosomal imbalances in gastric cancer. Correlation with histologic subtypes and tumor progression.
  Noguchi T, Wirtz HC, Michaelis S, Gabbert HE, Mueller W. Noguchi T, et al. Am J Clin Pathol. 2001 Jun;115(6):828-34. doi: 10.1309/2Q9E-3EP5-KYPK-VFGQ. Am J Clin Pathol. 2001. PMID: 11392878 Review.

Cited by

• Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.
  Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K. Gaiser T, et al. Cell Oncol (Dordr). 2011 Aug;34(4):337-42. doi: 10.1007/s13402-011-0032-x. Epub 2011 Jun 9. Cell Oncol (Dordr). 2011. PMID: 21656271
• Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
  Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H. Payne CM, et al. Clin Exp Gastroenterol. 2011;4:75-119. doi: 10.2147/CEG.S17114. Epub 2011 May 3. Clin Exp Gastroenterol. 2011. PMID: 21753893 Free PMC article.
• Protein _O_-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals.
  Hao H, Eberand BM, Larance M, Haltiwanger RS. Hao H, et al. Molecules. 2025 Mar 26;30(7):1470. doi: 10.3390/molecules30071470. Molecules. 2025. PMID: 40286076 Free PMC article. Review.
• A novel approach to simultaneously scan genes at fragile sites.
  Willem P, Brown J, Schouten J. Willem P, et al. BMC Cancer. 2006 Aug 8;6:205. doi: 10.1186/1471-2407-6-205. BMC Cancer. 2006. PMID: 16895604 Free PMC article.
• Overexpression of ERBB-2 was more frequently detected in malignant than benign pheochromocytomas by multiplex ligation-dependent probe amplification and immunohistochemistry.
  Yuan W, Wang W, Cui B, Su T, Ge Y, Jiang L, Zhou W, Ning G. Yuan W, et al. Endocr Relat Cancer. 2008 Mar;15(1):343-50. doi: 10.1677/ERC-07-0188. Endocr Relat Cancer. 2008. PMID: 18310300 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program