Focal adhesion kinase: in command and control of cell motility - PubMed (original) (raw)

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doi: 10.1038/nrm1549.

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• PMID: 15688067
• DOI: 10.1038/nrm1549

Review

Focal adhesion kinase: in command and control of cell motility

Satyajit K Mitra et al. Nat Rev Mol Cell Biol. 2005 Jan.

Abstract

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.

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