Proteolysis: from the lysosome to ubiquitin and the proteasome - PubMed (original) (raw)

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doi: 10.1038/nrm1552.

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• PMID: 15688069
• DOI: 10.1038/nrm1552

Review

Proteolysis: from the lysosome to ubiquitin and the proteasome

Aaron Ciechanover. Nat Rev Mol Cell Biol. 2005 Jan.

Abstract

How the genetic code is translated into proteins was a key focus of biological research before the 1980s, but how these proteins are degraded remained a neglected area. With the discovery of the lysosome, it was suggested that cellular proteins are degraded in this organelle. However, several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained obscure. The discovery of the ubiquitin-proteasome system resolved this enigma.

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