Multicomponent therapeutics for networked systems - PubMed (original) (raw)
Review
doi: 10.1038/nrd1609.
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- PMID: 15688074
- DOI: 10.1038/nrd1609
Review
Multicomponent therapeutics for networked systems
Curtis T Keith et al. Nat Rev Drug Discov. 2005 Jan.
Abstract
Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.
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