Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction - PubMed (original) (raw)

doi: 10.1016/j.devcel.2004.12.004.

Simge Akbulut, Judy Watson-Johnson, Ruth Simon, Thomas J Carroll, Reena Shakya, Isabelle Gross, Gail R Martin, Thomas Lufkin, Andrew P McMahon, Patricia D Wilson, Frank D Costantini, Ivor J Mason, Jonathan D Licht

Affiliations

• PMID: 15691764
• DOI: 10.1016/j.devcel.2004.12.004

Free article

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

M Albert Basson et al. Dev Cell. 2005 Feb.

Free article

Abstract

Intercellular signaling molecules and their receptors, whose expression must be tightly regulated in time and space, coordinate organogenesis. Regulators of intracellular signaling pathways provide an additional level of control. Here we report that loss of the receptor tyrosine kinase (RTK) antagonist, Sprouty1 (Spry1), causes defects in kidney development in mice. Spry1(-/-) embryos have supernumerary ureteric buds, resulting in the development of multiple ureters and multiplex kidneys. These defects are due to increased sensitivity of the Wolffian duct to GDNF/RET signaling, and reducing Gdnf gene dosage correspondingly rescues the Spry1 null phenotype. We conclude that the function of Spry1 is to modulate GDNF/RET signaling in the Wolffian duct, ensuring that kidney induction is restricted to a single site. These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations.

PubMed Disclaimer

Similar articles

• Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development.
  Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP. Majumdar A, et al. Development. 2003 Jul;130(14):3175-85. doi: 10.1242/dev.00520. Development. 2003. PMID: 12783789
• Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching.
  Kuure S, Sainio K, Vuolteenaho R, Ilves M, Wartiovaara K, Immonen T, Kvist J, Vainio S, Sariola H. Kuure S, et al. Mech Dev. 2005 Jun;122(6):765-80. doi: 10.1016/j.mod.2005.03.006. Mech Dev. 2005. PMID: 15905075
• Kidney development in the absence of Gdnf and Spry1 requires Fgf10.
  Michos O, Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F. Michos O, et al. PLoS Genet. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809. PLoS Genet. 2010. PMID: 20084103 Free PMC article.
• The GDNF/RET signaling pathway and human diseases.
  Takahashi M. Takahashi M. Cytokine Growth Factor Rev. 2001 Dec;12(4):361-73. doi: 10.1016/s1359-6101(01)00012-0. Cytokine Growth Factor Rev. 2001. PMID: 11544105 Review.
• The tip-top branching ureter.
  Sariola H, Sainio K. Sariola H, et al. Curr Opin Cell Biol. 1997 Dec;9(6):877-84. doi: 10.1016/s0955-0674(97)80091-9. Curr Opin Cell Biol. 1997. PMID: 9425354 Review.

Cited by

• Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice.
  Altés G, Olomí A, Perramon-Güell A, Hernández S, Casanovas A, Pérez A, Díaz-Tocados JM, Valdivielso JM, Megino C, Navaridas R, Matias-Guiu X, Klein OD, Egea J, Dolcet X, Yeramian A, Encinas M. Altés G, et al. Sci Rep. 2024 Aug 22;14(1):19479. doi: 10.1038/s41598-024-70529-w. Sci Rep. 2024. PMID: 39174793 Free PMC article.
• Sprouty1 is a broad mediator of cellular senescence.
  Anerillas C, Perramon-Güell A, Altés G, Cuesta S, Vaquero M, Olomí A, Rodríguez-Barrueco R, Llobet-Navàs D, Egea J, Dolcet X, Yeramian A, Encinas M. Anerillas C, et al. Cell Death Dis. 2024 Apr 26;15(4):296. doi: 10.1038/s41419-024-06689-4. Cell Death Dis. 2024. PMID: 38670941 Free PMC article.
• Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer.
  Li J, Ma R, Wang X, Lu Y, Chen J, Feng D, Zhou J, Xia K, Klein O, Xie H, Lu P. Li J, et al. Cell Death Dis. 2024 Apr 10;15(4):256. doi: 10.1038/s41419-024-06637-2. Cell Death Dis. 2024. PMID: 38600092 Free PMC article.
• The multifaceted links between hearing loss and chronic kidney disease.
  Greenberg D, Rosenblum ND, Tonelli M. Greenberg D, et al. Nat Rev Nephrol. 2024 May;20(5):295-312. doi: 10.1038/s41581-024-00808-2. Epub 2024 Jan 29. Nat Rev Nephrol. 2024. PMID: 38287134 Review.
• SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.
  Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S, Klein OD, Voss HU, Hadjantonakis AK, Elemento O, Martin LA, Seandel M. Luo Y, et al. Biol Reprod. 2023 Oct 13;109(4):533-551. doi: 10.1093/biolre/ioad089. Biol Reprod. 2023. PMID: 37552049 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Mouse Genome Informatics (MGI)