RNA polymerase IV directs silencing of endogenous DNA - PubMed (original) (raw)

. 2005 Apr 1;308(5718):118-20.

doi: 10.1126/science.1106910. Epub 2005 Feb 3.

Affiliations

• PMID: 15692015
• DOI: 10.1126/science.1106910

RNA polymerase IV directs silencing of endogenous DNA

A J Herr et al. Science. 2005.

Abstract

Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.

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