Functional correlates and prevalence of mild parkinsonian signs in a community population of older people - PubMed (original) (raw)
Comparative Study
. 2005 Feb;62(2):297-302.
doi: 10.1001/archneur.62.2.297.
Affiliations
- PMID: 15710859
- DOI: 10.1001/archneur.62.2.297
Comparative Study
Functional correlates and prevalence of mild parkinsonian signs in a community population of older people
Elan D Louis et al. Arch Neurol. 2005 Feb.
Abstract
Background: Mild parkinsonian signs (MPS) are associated with incident dementia and an increased risk of mortality. To our knowledge, the functional correlates of MPS have not been studied.
Objectives: To study the functional correlates of MPS, including self-reported and performance-based measures of function, and to determine the prevalence of MPS in a cohort of community-dwelling older people (aged >or=65 years).
Design: Participants (N = 1866) in the Washington Heights-Inwood Columbia Aging Project underwent a neurological assessment that included a modified motor portion of the Unified Parkinson's Disease Rating Scale, which yielded a parkinsonian sign score (range, 0-40) and parkinsonian sign subscores (axial function, rigidity, and tremor). A functional assessment included 3 self-reported measures of function and 2 performance-based tests. Participants with Parkinson disease were excluded.
Results: Mild parkinsonian signs were present in 469 (25.1%) of the 1866 participants. The parkinsonian sign score was correlated with functional and performance-based test scores (r = 0.24-0.32, P<.001). The axial function and rigidity subscores correlated to a greater extent with functional and performance-based test scores than did the tremor subscore. In analysis of covariance models, excluding participants with dementia and adjusting for age, sex, ethnicity, education, depressive symptoms, and medical illnesses (eg, arthritis), the parkinsonian sign score and age were strongly and independently associated with functional scores.
Conclusions: Mild parkinsonian signs, and particularly axial dysfunction, were associated with functional disability, including self-reported and performance-based measures of functional difficulty. Given the high prevalence of these signs in elderly persons, MPS may be a significant indicator of disability in elderly persons.
Similar articles
- Parkinsonian signs in older people in a community-based study: risk of incident dementia.
Louis ED, Tang MX, Mayeux R. Louis ED, et al. Arch Neurol. 2004 Aug;61(8):1273-6. doi: 10.1001/archneur.61.8.1273. Arch Neurol. 2004. PMID: 15313847 - Association between mild parkinsonian signs and mild cognitive impairment in a community.
Louis ED, Schupf N, Manly J, Marder K, Tang MX, Mayeux R. Louis ED, et al. Neurology. 2005 Apr 12;64(7):1157-61. doi: 10.1212/01.WNL.0000156157.97411.5E. Neurology. 2005. PMID: 15824340 - Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individuals.
Louis ED, Schupf N, Tang MX, Marder K, Luchsinger JA. Louis ED, et al. Arch Neurol. 2007 Nov;64(11):1646-51. doi: 10.1001/archneur.64.11.1646. Arch Neurol. 2007. PMID: 17998448 - Mild Parkinsonian signs: An overview of an emerging concept.
Louis ED, Bennett DA. Louis ED, et al. Mov Disord. 2007 Sep 15;22(12):1681-8. doi: 10.1002/mds.21433. Mov Disord. 2007. PMID: 17534951 Review. - Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations.
Buchanan SM, Richards M, Schott JM, Schrag A. Buchanan SM, et al. Mov Disord. 2021 Nov;36(11):2481-2493. doi: 10.1002/mds.28777. Epub 2021 Sep 25. Mov Disord. 2021. PMID: 34562045 Review.
Cited by
- Re: Comments on "Neuropsychological Comparison of Patients With Alzheimer's Disease and Dementia With Lewy Bodies": Author Response.
Kang S, Yoon SH, Na HK, Lee YG, Jeon S, Baik K, Sohn YH, Ye BS. Kang S, et al. J Clin Neurol. 2023 Sep;19(5):516-518. doi: 10.3988/jcn.2023.0210. J Clin Neurol. 2023. PMID: 37635432 Free PMC article. No abstract available. - Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study.
Vale TC, Cardoso FEC, da Silva DJ, Resende EPF, Maia DP, Cunningham MCQ, Guimarães HC, Machado JCB, Teixeira AL, Caramelli P, Barbosa MT. Vale TC, et al. BMC Neurol. 2023 Jul 21;23(1):276. doi: 10.1186/s12883-023-03290-8. BMC Neurol. 2023. PMID: 37479964 Free PMC article. - Effects of Cerebrovascular and Lewy Body Pathology on Parkinsonian Signs in Community-Dwelling Older Adults.
Agrawal S, Leurgans SE, Nag S, Oveisgharan S, Barnes LL, Bennett DA, Buchman AS, Schneider JA. Agrawal S, et al. Neurology. 2023 Aug 15;101(7):e754-e763. doi: 10.1212/WNL.0000000000207497. Epub 2023 Jul 12. Neurology. 2023. PMID: 37438127 Free PMC article. - Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.
Hengenius JB, Bohnen NI, Rosso A, Huppert TJ, Rosano C. Hengenius JB, et al. J Neuroimaging. 2022 Mar;32(2):352-362. doi: 10.1111/jon.12949. Epub 2021 Dec 27. J Neuroimaging. 2022. PMID: 34957653 Free PMC article. - Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents.
Nag S, Barnes LL, Yu L, Buchman AS, Bennett DA, Schneider JA, Wilson RS. Nag S, et al. Neurology. 2021 Aug 24;97(8):e825-e835. doi: 10.1212/WNL.0000000000012324. Epub 2021 Jun 4. Neurology. 2021. PMID: 34088871 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources