Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study - PubMed (original) (raw)

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study

N Talpur et al. Diabetes Obes Metab. 2005 Mar.

Abstract

Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.

Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension.

Material and methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.

Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula.

Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity.

PubMed Disclaimer

Cited by

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols.
Ge Q, Chen L, Chen K. Ge Q, et al. J Diabetes Res. 2017;2017:5837804. doi: 10.1155/2017/5837804. Epub 2017 Jul 3. J Diabetes Res. 2017. PMID: 28758131 Free PMC article. Review.
Beneficial effects of cinnamon on the metabolic syndrome, inflammation, and pain, and mechanisms underlying these effects - a review.
Shen Y, Jia LN, Honma N, Hosono T, Ariga T, Seki T. Shen Y, et al. J Tradit Complement Med. 2012 Jan;2(1):27-32. doi: 10.1016/s2225-4110(16)30067-0. J Tradit Complement Med. 2012. PMID: 24716111 Free PMC article. Review.
Curcumin and Health.
Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M. Pulido-Moran M, et al. Molecules. 2016 Feb 25;21(3):264. doi: 10.3390/molecules21030264. Molecules. 2016. PMID: 26927041 Free PMC article. Review.
Spices in a Product Affect Emotions: A Study with an Extruded Snack Product †.
Bell B, Adhikari K, Chambers E, Alavi S, King S, Haub M. Bell B, et al. Foods. 2017 Aug 18;6(8):70. doi: 10.3390/foods6080070. Foods. 2017. PMID: 28820459 Free PMC article.
Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review.
Zhou Q, Lei X, Fu S, Li Z, Chen Y, Long C, Li S, Chen Q. Zhou Q, et al. Front Physiol. 2022 Nov 24;13:960580. doi: 10.3389/fphys.2022.960580. eCollection 2022. Front Physiol. 2022. PMID: 36505061 Free PMC article.

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study - PubMed (original) (raw)