Whole-genome patterns of common DNA variation in three human populations - PubMed (original) (raw)

. 2005 Feb 18;307(5712):1072-9.

doi: 10.1126/science.1105436.

Affiliations

• PMID: 15718463
• DOI: 10.1126/science.1105436

Whole-genome patterns of common DNA variation in three human populations

David A Hinds et al. Science. 2005.

Abstract

Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations.

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Comment in

• Genetics. Harvesting medical information from the human family tree.
  Altshuler D, Clark AG. Altshuler D, et al. Science. 2005 Feb 18;307(5712):1052-3. doi: 10.1126/science.1109682. Science. 2005. PMID: 15718454 No abstract available.

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