Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis - PubMed (original) (raw)
Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis
S S Li et al. Histopathology. 2005 Mar.
Abstract
Aims: To assess, in tissue microarray (TMA), the proliferative activity of endometrial carcinoma using one of the minichromosome maintenance (MCM) proteins (MCM7), and to explore its potential value for prognosis. MCM proteins are essential for eukaryotic DNA replication and have recently been used to define the proliferative compartments in human tissues.
Methods and results: Immunohistochemistry for MCM7 and Ki67 was performed on TMAs constructed from 212 cases of endometrial carcinoma. MCM7 and Ki67 expression was quantified according to the extent of nuclear staining. An analysis was carried out of the association between MCM7 expression and that of Ki67 and the clinicopathological characteristics of endometrial carcinoma. MCM7 and Ki67 immunoreactivity was clearly evident in the nuclei of tumour cells. MCM7 and Ki67 labelling indices in endometrial carcinomas correlated with each other (P < 0.001). A significant correlation existed between the MCM7 labelling index and histological grade (P = 0.008) and patients' age at diagnosis (P < 0.001). Well-differentiated carcinomas and younger patients had a lower MCM7 index. Poor survival was observed in patients with endometrial carcinoma with a high MCM7 index (P = 0.03) and MCM7 was found to be an independent prognostic factor by multivariate analysis (P = 0.04). The Ki67 labelling index correlated with histological grade (P = 0.01) but had no significant prognostic impact (P = 0.50).
Conclusions: In this TMA study on endometrial carcinoma, MCM7 was found to be a more reliable and useful marker than Ki67 in assessing tumour proliferation and in the prognosis of patients.
Similar articles
- Expression of minichromosome maintenance 7 (MCM7) in small lung adenocarcinomas (pT1): Prognostic implication.
Fujioka S, Shomori K, Nishihara K, Yamaga K, Nosaka K, Araki K, Haruki T, Taniguchi Y, Nakamura H, Ito H. Fujioka S, et al. Lung Cancer. 2009 Aug;65(2):223-9. doi: 10.1016/j.lungcan.2008.11.007. Epub 2009 Jan 13. Lung Cancer. 2009. PMID: 19144445 - Minichromosome maintenance-7 and geminin are reliable prognostic markers in patients with oral squamous cell carcinoma: immunohistochemical study.
Tamura T, Shomori K, Haruki T, Nosaka K, Hamamoto Y, Shiomi T, Ryoke K, Ito H. Tamura T, et al. J Oral Pathol Med. 2010 Apr;39(4):328-34. doi: 10.1111/j.1600-0714.2009.00861.x. Epub 2010 Feb 2. J Oral Pathol Med. 2010. PMID: 20136698 - Minichromosome maintenance protein 7 in colorectal cancer: implication of prognostic significance.
Nishihara K, Shomori K, Fujioka S, Tokuyasu N, Inaba A, Osaki M, Ogawa T, Ito H. Nishihara K, et al. Int J Oncol. 2008 Aug;33(2):245-51. Int J Oncol. 2008. PMID: 18636144 - Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology.
Tachibana KE, Gonzalez MA, Coleman N. Tachibana KE, et al. J Pathol. 2005 Jan;205(2):123-9. doi: 10.1002/path.1708. J Pathol. 2005. PMID: 15643673 Review. - Prognostic factors in endometrial neoplasia: old and new.
Nogales FF. Nogales FF. Curr Opin Obstet Gynecol. 1996 Feb;8(1):74-8. Curr Opin Obstet Gynecol. 1996. PMID: 8777263 Review.
Cited by
- Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma.
Hotton J, Agopiantz M, Leroux A, Charra-Brunaud C, Marie B, Busby-Venner H, Morel O, Guéant JL, Vignaud JM, Battaglia-Hsu SF, Gauchotte G. Hotton J, et al. Virchows Arch. 2018 Apr;472(4):623-633. doi: 10.1007/s00428-017-2278-9. Epub 2017 Dec 14. Virchows Arch. 2018. PMID: 29243125 - Identification of candidate cancer genes involved in human retinoblastoma by data mining.
Yang J, Zhao JJ, Zhu Y, Xiong W, Lin JY, Ma X. Yang J, et al. Childs Nerv Syst. 2008 Aug;24(8):893-900. doi: 10.1007/s00381-008-0595-7. Epub 2008 Mar 19. Childs Nerv Syst. 2008. PMID: 18350306 - Prognostic biomarkers in endometrial and ovarian carcinoma.
Matias-Guiu X, Davidson B. Matias-Guiu X, et al. Virchows Arch. 2014 Mar;464(3):315-31. doi: 10.1007/s00428-013-1509-y. Epub 2014 Feb 7. Virchows Arch. 2014. PMID: 24504546 Review. - Oncogenic activity of MCM7 transforming cluster.
Luo JH. Luo JH. World J Clin Oncol. 2011 Feb 10;2(2):120-4. doi: 10.5306/wjco.v2.i2.120. World J Clin Oncol. 2011. PMID: 21603321 Free PMC article. - Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth.
Zhang XY, Tang LZ, Ren BG, Yu YP, Nelson J, Michalopoulos G, Luo JH. Zhang XY, et al. Am J Pathol. 2013 Mar;182(3):796-805. doi: 10.1016/j.ajpath.2012.11.020. Epub 2013 Jan 11. Am J Pathol. 2013. PMID: 23313748 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources