The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy - PubMed (original) (raw)

Clinical Trial

The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy

Maria Paz Loayza Hidalgo et al. Anesth Analg. 2005 Mar.

Abstract

We assessed the effect of small clonidine doses on anxiolysis, analgesia, and hemodynamic stability in patients undergoing abdominal hysterectomy. A total of 61 patients, ASA status I-II, were randomly assigned to receive either oral clonidine 100 microg (n = 29) or placebo (n = 32) before surgery and 24 h after surgery. The use of clonidine resulted in anxiolysis and analgesia throughout the 72 h after surgery, although the subjects who received clonidine were sleepier than the control group for the first 6 h after surgery. The number needed to treat was 3 (95% confidence interval [CI], 1.72-9.42) to prevent intense anxiety in patients with moderate to intense postoperative pain, compared with 40 (95% CI, 18.79-99.68) in the absence of pain or with mild pain. In the treated patients, 68% had an average heart rate less than 70 bpm during surgery, compared with 21.40% in the placebo group (number needed to treat, 2; 95% CI, 1.29-2.80). The clonidine patients required small ropivacaine doses during the surgery but not less morphine by patient-controlled analgesia. A clinically relevant anxiolytic effect was found in patients who received oral clonidine in the perioperative period, and this suggests that clonidine might be a useful therapeutic alternative to other preoperative sedatives.

PubMed Disclaimer

Cited by

Oral analgesia for relieving post-caesarean pain.
Mkontwana N, Novikova N. Mkontwana N, et al. Cochrane Database Syst Rev. 2015 Mar 29;2015(3):CD010450. doi: 10.1002/14651858.CD010450.pub2. Cochrane Database Syst Rev. 2015. PMID: 25821010 Free PMC article. Review.
Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial.
Palmer ACS, Zortea M, Souza A, Santos V, Biazús JV, Torres ILS, Fregni F, Caumo W. Palmer ACS, et al. PLoS One. 2020 Apr 17;15(4):e0231379. doi: 10.1371/journal.pone.0231379. eCollection 2020. PLoS One. 2020. PMID: 32302347 Free PMC article. Clinical Trial.
Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia.
Lewis SR, Nicholson A, Smith AF, Alderson P. Lewis SR, et al. Cochrane Database Syst Rev. 2015 Aug 10;2015(8):CD011107. doi: 10.1002/14651858.CD011107.pub2. Cochrane Database Syst Rev. 2015. PMID: 26256531 Free PMC article. Review.
Post-operative Weaning of Opioids After Ambulatory Surgery: the Importance of Physician Stewardship.
Roth B, Boateng A, Berken A, Carlyle D, Vadivelu N. Roth B, et al. Curr Pain Headache Rep. 2018 May 3;22(6):40. doi: 10.1007/s11916-018-0694-4. Curr Pain Headache Rep. 2018. PMID: 29725865 Review.

References

1. Moyers JR. Preoperative medication. In: Barash PG, Cullen BF, Stoelting RK, eds. Clinical anesthesia. 3rd ed. Philadelphia: Lippincott-Raven, 1997:519–33.
1. Kain ZN, Mayes LC, Bell C, et al. Premedication in the United States: a status report. Anesth Analg 1997;84:427–32.
1. Kain ZN, Sevarino FB, Rinder C, et al. Preoperative anxiolysis and postoperative recovery in women undergoing abdominal hysterectomy. Anesthesiology 2001;94:415–22.
1. Caumo W, Hidalgo MPL, Schmidt AP, et al. Effect of preoperative anxiolysis on postoperative pain response in patients undergoing total abdominal hysterectomy. Anesthesia 2002;57:740–6.
1. Quintin L, Viale JP, Annat G, et al. Oxygen uptake after major abdominal surgery: effect of clonidine. Anesthesiology 1991;74:236–41.

The clinical effect of small oral clonidine doses on perioperative outcomes in patients undergoing abdominal hysterectomy - PubMed (original) (raw)