Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics - PubMed (original) (raw)

Comparative Study

Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics

Yufeng Yao et al. Infect Immun. 2005 Mar.

Abstract

Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.

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Figures

FIG. 1.

FIG. 1.

Relatedness of strains used for microarray-based investigation of gene distribution in this study. Strain names for strains from infections are according to Galdbart et al. (5), by whom the strains were first described. Control strains are numbered from c1 to c22 and are also from that study. Absence of genes is shown in blue; presence of genes is shown in yellow and red. A dendrogram is shown on the right. The analysis was performed with GeneSpring software.

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