GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis - PubMed (original) (raw)

GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis

Jason E Comer et al. Infect Immun. 2005 Mar.

Abstract

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

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