A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes - PubMed (original) (raw)

. 1992 Apr 30;356(6372):768-74.

doi: 10.1038/356768a0.

Affiliations

• PMID: 1574116
• DOI: 10.1038/356768a0

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

N A Thornberry et al. Nature. 1992.

Abstract

Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and the design of potent peptide aldehyde inhibitors are described. Purification and cloning of the complementary DNA indicates that IL-1 beta-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target.

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