Postsynaptic receptor trafficking underlying a form of associative learning - PubMed (original) (raw)

. 2005 Apr 1;308(5718):83-8.

doi: 10.1126/science.1103944. Epub 2005 Mar 3.

Affiliations

• PMID: 15746389
• DOI: 10.1126/science.1103944

Postsynaptic receptor trafficking underlying a form of associative learning

Simon Rumpel et al. Science. 2005.

Abstract

To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in the lateral amygdala, a brain structure essential for this learning process. Furthermore, memory was reduced if AMPA receptor synaptic incorporation was blocked in as few as 10 to 20% of lateral amygdala neurons. Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy.

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Comment in

• AMPA receptor trafficking and GluR1.
  Grant SG. Grant SG. Science. 2005 Oct 14;310(5746):234-5; author reply 234-5. doi: 10.1126/science.310.5746.234. Science. 2005. PMID: 16224003 No abstract available.

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