Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells - PubMed (original) (raw)
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
Claudia Di Giacinto et al. J Immunol. 2005.
Abstract
Recent studies of murine models of mucosal inflammation suggest that, whereas some kinds of bacterial microflora are inducers of disease, others, known as probiotics, prevent disease. In the present study, we analyzed the regulatory cytokine and cell response to probiotic (VSL#3) administration in the context of the Th1 T cell colitis induced by trinitrobenzene sulfonic acid treatment of SJL/J mice. Daily administration of probiotics for 3 wk to mice during a remission period between a first and second course of colitis induced by trinitrobenzene sulfonic acid, resulted in a milder form of recurrent colitis than observed in mice administered PBS during this same period. This protective effect was attributable to effects on the lamina propria mononuclear cell (LPMC) population, because it could be transferred by LPMC from probiotic-treated mice to naive mice. Probiotic administration was associated with an early increase in the production of IL-10 and an increased number of regulatory CD4+ T cells bearing surface TGF-beta in the form of latency-associated protein (LAP) (LAP+ T cells). The latter were dependent on the IL-10 production because administration of anti-IL-10R mAb blocked their appearance. Finally, the LAP+ T cells were essential to the protective effect of probiotics because administration of anti-IL-10R or anti-TGF-beta at the initiation of recurrent colitis induction or depletion of LAP+ T cells from LPMC abolished the latter's capacity to transfer protection to naive recipients. These studies show that probiotic (VSL#3) administration during a remission period ameliorates the severity of recurrent colitis by inducing an immunoregulatory response involving TGF-beta-bearing regulatory cells.
Similar articles
- Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.
Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W. Neurath MF, et al. J Exp Med. 1996 Jun 1;183(6):2605-16. doi: 10.1084/jem.183.6.2605. J Exp Med. 1996. PMID: 8676081 Free PMC article. - The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis.
Fuss IJ, Boirivant M, Lacy B, Strober W. Fuss IJ, et al. J Immunol. 2002 Jan 15;168(2):900-8. doi: 10.4049/jimmunol.168.2.900. J Immunol. 2002. PMID: 11777988 - Bifidobacterium infantis attenuates colitis by regulating T cell subset responses.
Zuo L, Yuan KT, Yu L, Meng QH, Chung PC, Yang DH. Zuo L, et al. World J Gastroenterol. 2014 Dec 28;20(48):18316-29. doi: 10.3748/wjg.v20.i48.18316. World J Gastroenterol. 2014. PMID: 25561798 Free PMC article. - Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation.
Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, Neurath M. Strober W, et al. Immunol Today. 1997 Feb;18(2):61-4. doi: 10.1016/s0167-5699(97)01000-1. Immunol Today. 1997. PMID: 9057354 Review. - Cytokines mediating the induction of chronic colitis and colitis-associated fibrosis.
Fichtner-Feigl S, Strober W, Geissler EK, Schlitt HJ. Fichtner-Feigl S, et al. Mucosal Immunol. 2008 Nov;1 Suppl 1(0 1):S24-7. doi: 10.1038/mi.2008.41. Mucosal Immunol. 2008. PMID: 19079223 Free PMC article. Review.
Cited by
- Research progress on the microbiota in bladder cancer tumors.
Lou K, Chi J, Wu J, Ma J, Liu S, Cui Y. Lou K, et al. Front Cell Infect Microbiol. 2024 Apr 8;14:1374944. doi: 10.3389/fcimb.2024.1374944. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38650736 Free PMC article. Review. - The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer.
Kustrimovic N, Bilato G, Mortara L, Baci D. Kustrimovic N, et al. Int J Mol Sci. 2024 Jan 31;25(3):1732. doi: 10.3390/ijms25031732. Int J Mol Sci. 2024. PMID: 38339010 Free PMC article. Review. - The effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on cytokines and their related molecules: An ex vivo study on patients with systemic lupus erythematosus.
Alaei A, Mahmoudi M, Sahebari M, Vahidi Z, Tabasi N, Rastin M. Alaei A, et al. Arch Rheumatol. 2023 Oct 7;38(4):642-652. doi: 10.46497/ArchRheumatol.2023.9941. eCollection 2023 Dec. Arch Rheumatol. 2023. PMID: 38125063 Free PMC article. - Probiotic and Muscadine Grape Extract Interventions Shift the Gut Microbiome and Improve Metabolic Parameters in Female C57BL/6 Mice.
Newman TM, Wilson AS, Clear KYJ, Tallant EA, Gallagher PE, Cook KL. Newman TM, et al. Cells. 2023 Nov 10;12(22):2599. doi: 10.3390/cells12222599. Cells. 2023. PMID: 37998334 Free PMC article. - Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis.
Guo N, Lv LL. Guo N, et al. Immun Inflamm Dis. 2023 Oct;11(10):e1045. doi: 10.1002/iid3.1045. Immun Inflamm Dis. 2023. PMID: 37904683 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials