Human metapneumovirus RNA in encephalitis patient - PubMed (original) (raw)

Case Reports

doi: 10.3201/eid1103.040676.

Thomas Glatzel, Tilman Geikowski, Bärbel Scheibner, Bertfried Matz, Lutz Bindl, Mark Born, Sergei Viazov, Anja Wilkesmann, Gisela Knöpfle, Michael Roggendorf, Arne Simon

Affiliations

• PMID: 15757568
• PMCID: PMC3298257
• DOI: 10.3201/eid1103.040676

Case Reports

Human metapneumovirus RNA in encephalitis patient

Oliver Schildgen et al. Emerg Infect Dis. 2005 Mar.

Abstract

We describe a fatal case of encephalitis that might be correlated with primary human metapneumovirus (HMPV) encephalitis. Postmortem HMPV RNA was detected in brain and lung tissue samples from the patient. Furthermore, HMPV RNA was found in culture fluids from cells coincubated with lung tissue.

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Figures

Figure 1

Axial T1-weighted magnetic resonance imaging (MRI) scan (A) and coronal fluid attenuated inversion recovery (FLAIR) (B) show multifocal, mainly cortical and subcortical lesions of high signal intensity, which are most probably caused by multifocal encephalitis. C) Nonenhanced axial computed tomographic (CT) scan performed 2 days after the MRI shows multiple, hypodense lesions and signs of general edema. Additionally, it shows a hyperdense arachnoid collection that was not yet visible on the MRI 2 days before (panels A and B).

Figure 2

Alignment of 302 nucleotide human metapneumovirus (HMPV) sequences amplified from brain and lung tissues of the patient and from the supernatant of infected Vero cell culture. Sequence of the HMPV strain NLD00-1 was used as a prototype sequence. Conditions of the reverse transcription–polymerase chain reaction were described elsewhere (5).

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