New semantic learning and generalization in a patient with amnesia - PubMed (original) (raw)
Comparative Study
New semantic learning and generalization in a patient with amnesia
Craig Stark et al. Neuropsychology. 2005 Mar.
Abstract
New learning of semantic information is impaired in amnesia. Several reports have demonstrated that "errorless" learning techniques have allowed patients with amnesia to acquire at least some form of new semantic information, although this information appears to be relatively inflexible. Using insights and principles from connectionist modeling of cortical and medial temporal lobe memory systems, the authors describe why errorless learning procedures act as a poor proxy for the medial temporal lobe, suggesting that they artificially eliminate the variability that defines semantic information. The authors trained a patient with severe amnesia on new semantic sentences both with and without variance and then tested him on both repeated and related novel sentences to assess generalization. He successfully learned new semantic information in both conditions but demonstrated better generalization of semantic concepts following training with variance.
((c) 2005 APA, all rights reserved).
Similar articles
- Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories?
Skotko BG, Kensinger EA, Locascio JJ, Einstein G, Rubin DC, Tupler LA, Krendl A, Corkin S. Skotko BG, et al. Neuropsychology. 2004 Oct;18(4):756-69. doi: 10.1037/0894-4105.18.4.756. Neuropsychology. 2004. PMID: 15506844 - Remembering and forgetting of semantic knowledge in amnesia: a 16-year follow-up investigation of RFR.
McCarthy RA, Kopelman MD, Warrington EK. McCarthy RA, et al. Neuropsychologia. 2005;43(3):356-72. doi: 10.1016/j.neuropsychologia.2004.06.024. Epub 2004 Oct 2. Neuropsychologia. 2005. PMID: 15707613 - A case study of amnesia: exploring a paradigm for new semantic learning and generalization.
Stark S, Gordon B, Stark C. Stark S, et al. Brain Inj. 2008 Mar;22(3):283-92. doi: 10.1080/02699050801953081. Brain Inj. 2008. PMID: 18297600 - Dissociations in cognitive memory: the syndrome of developmental amnesia.
Vargha-Khadem F, Gadian DG, Mishkin M. Vargha-Khadem F, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1435-40. doi: 10.1098/rstb.2001.0951. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11571034 Free PMC article. Review. - [Knowing without remembering: the contribution of developmental amnesia].
Lebrun-Givois C, Guillery-Girard B, Thomas-Anterion C, Laurent B. Lebrun-Givois C, et al. Rev Neurol (Paris). 2008 May;164 Suppl 3:S114-8. doi: 10.1016/S0035-3787(08)73301-0. Rev Neurol (Paris). 2008. PMID: 18675036 Review. French.
Cited by
- Word Learning as a Window to Memory and Rehabilitation Outcomes in Traumatic Brain Injury.
Morrow EL, Duff MC. Morrow EL, et al. Am J Speech Lang Pathol. 2023 Mar 23;32(2S):956-965. doi: 10.1044/2022_AJSLP-22-00073. Epub 2022 Nov 10. Am J Speech Lang Pathol. 2023. PMID: 36356223 Free PMC article. - Semantic Memory and the Hippocampus: Revisiting, Reaffirming, and Extending the Reach of Their Critical Relationship.
Duff MC, Covington NV, Hilverman C, Cohen NJ. Duff MC, et al. Front Hum Neurosci. 2020 Jan 24;13:471. doi: 10.3389/fnhum.2019.00471. eCollection 2019. Front Hum Neurosci. 2020. PMID: 32038203 Free PMC article. Review. - Hand gestures support word learning in patients with hippocampal amnesia.
Hilverman C, Cook SW, Duff MC. Hilverman C, et al. Hippocampus. 2018 Jun;28(6):406-415. doi: 10.1002/hipo.22840. Epub 2018 Mar 23. Hippocampus. 2018. PMID: 29506316 Free PMC article. Clinical Trial. - Remote semantic memory is impoverished in hippocampal amnesia.
Klooster NB, Duff MC. Klooster NB, et al. Neuropsychologia. 2015 Dec;79(Pt A):42-52. doi: 10.1016/j.neuropsychologia.2015.10.017. Epub 2015 Oct 22. Neuropsychologia. 2015. PMID: 26474741 Free PMC article. - Learning in Alzheimer's disease is facilitated by social interaction.
Duff MC, Gallegos DR, Cohen NJ, Tranel D. Duff MC, et al. J Comp Neurol. 2013 Dec 15;521(18):4356-69. doi: 10.1002/cne.23433. J Comp Neurol. 2013. PMID: 23881834 Free PMC article. Clinical Trial.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources