Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers - PubMed (original) (raw)
Review
Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers
Andrei I Ivanov et al. Bioessays. 2005 Apr.
Abstract
Tight junctions (TJ) and adherens junctions (AJ) regulate cell-cell adhesion and barrier function of simple polarized epithelia. These junctions are positioned in the apical end of the lateral plasma membrane and form the so-called apical junctional complex (AJC). Although initially seen as purely structural features, the AJC is now known to play important roles in cell differentiation and proliferation. The AJC is a highly dynamic entity, undergoing rapid remodeling during normal epithelial morphogenesis and under pathologic conditions. There is growing evidence that remodeling of the AJC is mediated by internalization of junctional proteins. This review summarizes what is known about endocytic pathways, intracellular destinations and signaling cascades involved in internalization of AJC proteins. Potential biological roles for AJC endocytosis in maintaining functional apical junctions, reversible opening of epithelial barrier and disruption of intercellular adhesion are also discussed.
Copyright 2005 Wiley periodicals, Inc.
Similar articles
- The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption.
Ivanov AI, Nusrat A, Parkos CA. Ivanov AI, et al. Novartis Found Symp. 2004;263:115-24; discussion 124-32, 211-8. Novartis Found Symp. 2004. PMID: 15669638 Review. - Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Sugiyama Y, Prescott AR, Tholozan FM, Ohno S, Quinlan RA. Sugiyama Y, et al. Exp Eye Res. 2008 Jul;87(1):64-70. doi: 10.1016/j.exer.2008.03.017. Epub 2008 Apr 3. Exp Eye Res. 2008. PMID: 18508048 - The keratin-binding protein Albatross regulates polarization of epithelial cells.
Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, Hayashi Y, Izawa I, Sasoh M, Uji Y, Kaibuchi K, Kiyono T, Inagaki M. Sugimoto M, et al. J Cell Biol. 2008 Oct 6;183(1):19-28. doi: 10.1083/jcb.200803133. J Cell Biol. 2008. PMID: 18838552 Free PMC article. - Molecular perspective on tight-junction assembly and epithelial polarity.
Miyoshi J, Takai Y. Miyoshi J, et al. Adv Drug Deliv Rev. 2005 Apr 25;57(6):815-55. doi: 10.1016/j.addr.2005.01.008. Adv Drug Deliv Rev. 2005. PMID: 15820555 Review. - Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex.
Ivanov AI, McCall IC, Parkos CA, Nusrat A. Ivanov AI, et al. Mol Biol Cell. 2004 Jun;15(6):2639-51. doi: 10.1091/mbc.e04-02-0163. Epub 2004 Mar 26. Mol Biol Cell. 2004. PMID: 15047870 Free PMC article.
Cited by
- Tight Junction Proteins and the Biology of Hepatobiliary Disease.
Roehlen N, Roca Suarez AA, El Saghire H, Saviano A, Schuster C, Lupberger J, Baumert TF. Roehlen N, et al. Int J Mol Sci. 2020 Jan 28;21(3):825. doi: 10.3390/ijms21030825. Int J Mol Sci. 2020. PMID: 32012812 Free PMC article. Review. - Spectrin-adducin membrane skeleton: A missing link between epithelial junctions and the actin cytoskeletion?
Naydenov NG, Ivanov AI. Naydenov NG, et al. Bioarchitecture. 2011 Jul;1(4):186-191. doi: 10.4161/bioa.1.4.17642. Epub 2011 Jul 1. Bioarchitecture. 2011. PMID: 22069512 Free PMC article. - Aroclor1254 disrupts the blood-testis barrier by promoting endocytosis and degradation of junction proteins via p38 MAPK pathway.
Jia X, Xu Y, Wu W, Fan Y, Wang G, Zhang T, Su W. Jia X, et al. Cell Death Dis. 2017 May 25;8(5):e2823. doi: 10.1038/cddis.2017.224. Cell Death Dis. 2017. PMID: 28542131 Free PMC article. - Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens.
Ireton K. Ireton K. Open Biol. 2013 Jul 17;3(7):130079. doi: 10.1098/rsob.130079. Open Biol. 2013. PMID: 23864553 Free PMC article. Review. - Scaffolding protein GOPC regulates tight junction structure.
Lu R, Stewart L, Wilson JM. Lu R, et al. Cell Tissue Res. 2015 May;360(2):321-32. doi: 10.1007/s00441-014-2088-1. Epub 2015 Jan 24. Cell Tissue Res. 2015. PMID: 25616555 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- DK55679/DK/NIDDK NIH HHS/United States
- DK59888/DK/NIDDK NIH HHS/United States
- DK61379/DK/NIDDK NIH HHS/United States
- DK64399/DK/NIDDK NIH HHS/United States
- DK77564/DK/NIDDK NIH HHS/United States
LinkOut - more resources
Full Text Sources