Nuclear lamins: building blocks of nuclear structure and function - PubMed (original) (raw)
Review
. 2005:264:3-16; discussion 16-21, 227-30.
Affiliations
- PMID: 15773744
Review
Nuclear lamins: building blocks of nuclear structure and function
Robert D Goldman et al. Novartis Found Symp. 2005.
Abstract
The cell nucleus is surrounded by a complex membranous envelope which separates the nucleoplasm from the cytoplasm. Unlike the cytoplasm, the nucleoplasm is not subdivided into membrane-bound compartments, which allows for the efficient segregation of a wide range of complex metabolic activities. In the absence of such membrane compartmentalization, the nucleus is faced with the daunting task of efficiently segregating and interconnecting an enormous array of critically important functions. These include the assembly of the large multi-component complexes or 'factories' involved in DNA replication and transcription. These structures are dynamic as they are assembled and disassembled both spatially and temporally at different times, implying the existence of an infrastructure or nucleoskeleton responsible for establishing and maintaining a complex nuclear architecture. There is increasing evidence that the nuclear lamins are essential elements of this nuclear infrastructure, and that their proper assembly and organization are required for numerous essential nuclear functions. Our goal has been to determine the roles of the nuclear lamins in vital nuclear processes including DNA replication and transcription. The hypothesis directing our investigations is that the lamins form a 3D network that courses throughout the nucleoplasm providing an infrastructure for the assembly and distribution of numerous multicomponent complexes involved in a wide range of nuclear functions.
Similar articles
- Nuclear lamins: their structure, assembly, and interactions.
Stuurman N, Heins S, Aebi U. Stuurman N, et al. J Struct Biol. 1998;122(1-2):42-66. doi: 10.1006/jsbi.1998.3987. J Struct Biol. 1998. PMID: 9724605 Review. - Review: nuclear lamins--structural proteins with fundamental functions.
Gruenbaum Y, Wilson KL, Harel A, Goldberg M, Cohen M. Gruenbaum Y, et al. J Struct Biol. 2000 Apr;129(2-3):313-23. doi: 10.1006/jsbi.2000.4216. J Struct Biol. 2000. PMID: 10806082 Review. - Dynamics of nuclear lamina assembly and disassembly.
Broers JL, Ramaekers FC. Broers JL, et al. Symp Soc Exp Biol. 2004;(56):177-92. Symp Soc Exp Biol. 2004. PMID: 15565881 Review. - Nuclear lamins, diseases and aging.
Mattout A, Dechat T, Adam SA, Goldman RD, Gruenbaum Y. Mattout A, et al. Curr Opin Cell Biol. 2006 Jun;18(3):335-41. doi: 10.1016/j.ceb.2006.03.007. Epub 2006 Apr 24. Curr Opin Cell Biol. 2006. PMID: 16632339 Review. - Nuclear lamins: building blocks of nuclear architecture.
Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP. Goldman RD, et al. Genes Dev. 2002 Mar 1;16(5):533-47. doi: 10.1101/gad.960502. Genes Dev. 2002. PMID: 11877373 Review. No abstract available.
Cited by
- From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.
Cox LS, Faragher RG. Cox LS, et al. Cell Mol Life Sci. 2007 Oct;64(19-20):2620-41. doi: 10.1007/s00018-007-7123-x. Cell Mol Life Sci. 2007. PMID: 17660942 Free PMC article. Review. - Identification of COMMD1 as a novel lamin A binding partner.
Jiang Z, Chen W, Zhou J, Peng Q, Zheng H, Yuan Y, Cui H, Zhao W, Sun X, Zhou Z, Liu X. Jiang Z, et al. Mol Med Rep. 2019 Aug;20(2):1790-1796. doi: 10.3892/mmr.2019.10419. Epub 2019 Jun 24. Mol Med Rep. 2019. PMID: 31257505 Free PMC article. - A-type nuclear lamins act as transcriptional repressors when targeted to promoters.
Lee DC, Welton KL, Smith ED, Kennedy BK. Lee DC, et al. Exp Cell Res. 2009 Apr 1;315(6):996-1007. doi: 10.1016/j.yexcr.2009.01.003. Epub 2009 Jan 18. Exp Cell Res. 2009. PMID: 19272320 Free PMC article. - A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome.
Cleveland RH, Gordon LB, Kleinman ME, Miller DT, Gordon CM, Snyder BD, Nazarian A, Giobbie-Hurder A, Neuberg D, Kieran MW. Cleveland RH, et al. Pediatr Radiol. 2012 Sep;42(9):1089-98. doi: 10.1007/s00247-012-2423-1. Epub 2012 Jul 1. Pediatr Radiol. 2012. PMID: 22752073 Free PMC article. - Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.
Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS. Fritz AJ, et al. J Cell Biochem. 2016 Jan;117(1):9-19. doi: 10.1002/jcb.25280. J Cell Biochem. 2016. PMID: 26192137 Free PMC article.