Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex - PubMed (original) (raw)

. 2005 Mar 18;307(5716):1776-8.

doi: 10.1126/science.1104882.

Affiliations

• PMID: 15774759
• DOI: 10.1126/science.1104882

Free article

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex

Shuzhen Hao et al. Science. 2005.

Free article

Abstract

Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Cells in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.

PubMed Disclaimer

Similar articles

• Mechanisms of food intake repression in indispensable amino acid deficiency.
  Gietzen DW, Hao S, Anthony TG. Gietzen DW, et al. Annu Rev Nutr. 2007;27:63-78. doi: 10.1146/annurev.nutr.27.061406.093726. Annu Rev Nutr. 2007. PMID: 17328672 Review.
• The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function.
  Rudell JB, Rechs AJ, Kelman TJ, Ross-Inta CM, Hao S, Gietzen DW. Rudell JB, et al. J Neurosci. 2011 Feb 2;31(5):1583-90. doi: 10.1523/JNEUROSCI.4934-10.2011. J Neurosci. 2011. PMID: 21289166 Free PMC article.
• Effects of essential amino acid deficiency: down-regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex.
  Sharp JW, Ross-Inta CM, Baccelli I, Payne JA, Rudell JB, Gietzen DW. Sharp JW, et al. J Neurochem. 2013 Nov;127(4):520-30. doi: 10.1111/jnc.12403. Epub 2013 Sep 12. J Neurochem. 2013. PMID: 24024616 Free PMC article.
• The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.
  Hao S, Ross-Inta CM, Gietzen DW. Hao S, et al. Pharmacol Biochem Behav. 2010 Jan;94(3):333-40. doi: 10.1016/j.pbb.2009.09.014. Epub 2009 Oct 1. Pharmacol Biochem Behav. 2010. PMID: 19800362 Free PMC article.
• The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.
  Gietzen DW, Aja SM. Gietzen DW, et al. Mol Neurobiol. 2012 Oct;46(2):332-48. doi: 10.1007/s12035-012-8283-8. Epub 2012 Jun 7. Mol Neurobiol. 2012. PMID: 22674217 Free PMC article. Review.

Cited by

• Unraveling cysteine deficiency-associated rapid weight loss.
  Varghese A, Gusarov I, Gamallo-Lana B, Dolgonos D, Mankan Y, Shamovsky I, Phan M, Jones R, Gomez-Jenkins M, White E, Wang R, Jones D, Papagiannakopoulos T, Pacold ME, Mar AC, Littman DR, Nudler E. Varghese A, et al. bioRxiv [Preprint]. 2024 Jul 31:2024.07.30.605703. doi: 10.1101/2024.07.30.605703. bioRxiv. 2024. PMID: 39131293 Free PMC article. Preprint.
• A brain-derived insulin signal encodes protein satiety for nutrient-specific feeding inhibition.
  Li X, Yang Y, Bai X, Wang X, Tan H, Chen Y, Zhu Y, Liu Q, Wu MN, Li Y. Li X, et al. Cell Rep. 2024 Jun 25;43(6):114282. doi: 10.1016/j.celrep.2024.114282. Epub 2024 May 24. Cell Rep. 2024. PMID: 38795342 Free PMC article.
• AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
  Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q. Deng B, et al. Cell Death Dis. 2024 Mar 23;15(3):233. doi: 10.1038/s41419-024-06577-x. Cell Death Dis. 2024. PMID: 38521813 Free PMC article.
• Immunometabolism of dendritic cells in health and disease.
  Guo C, Chi H. Guo C, et al. Adv Immunol. 2023;160:83-116. doi: 10.1016/bs.ai.2023.10.002. Epub 2023 Oct 25. Adv Immunol. 2023. PMID: 38042587 Review.
• Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation-induced premature aging mice.
  Li W, Wang X, Dong Y, Huo Q, Yue T, Wu X, Lu L, Zhang J, Zhao Y, Dong H, Li D. Li W, et al. Aging Cell. 2023 Nov;22(11):e13976. doi: 10.1111/acel.13976. Epub 2023 Aug 31. Aging Cell. 2023. PMID: 37650560 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal