Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome - PubMed (original) (raw)
Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome
Kirsten Tillisch et al. Am J Gastroenterol. 2005 Apr.
Abstract
Background: Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized.
Objectives: (i) To determine a set of bowel habit symptom criteria, which most specifically identifies IBS patients with an alternating bowel habit, (ii) to describe IBS-A bowel symptom patterns, and (iii) to compare clinical characteristics among IBS-A, constipation-predominant (IBS-C), and diarrhea-predominant IBS (IBS-D).
Methods: One thousand one hundred and two Rome I positive IBS patients were analyzed. Three sets of potential criteria for IBS-A were developed and compared by multirater Kappa test. Gastrointestinal, psychological, extraintestinal symptoms, and health-related quality of life were compared in IBS-A, IBS-C, and IBS-D using chi(2) test and analysis of variance (ANOVA).
Results: Stool consistency was determined to be the most specific criteria for alternating bowel habits. IBS-A patients reported rapid fluctuations in bowel habits with short symptom flares and remissions. There was a greater prevalence of psychological and extraintestinal symptoms in the IBS-A subgroup compared to IBS-C and IBS-D. No differences were seen between bowel habit subtypes in health-related quality of life.
Conclusions: IBS-A patients have rapidly fluctuating symptoms and increased psychological comorbidity, which should be taken into account for clinical practice and clinical trials.
Similar articles
- Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III.
Ersryd A, Posserud I, Abrahamsson H, Simrén M. Ersryd A, et al. Aliment Pharmacol Ther. 2007 Sep 15;26(6):953-61. doi: 10.1111/j.1365-2036.2007.03422.x. Aliment Pharmacol Ther. 2007. PMID: 17767480 - Impact of upper digestive symptoms in patients with irritable bowel syndrome.
Balboa A, Mearin F, Badía X, Benavent J, Caballero AM, Domínguez-Muñoz JE, Garrigues V, Piqué JM, Roset M, Cucala M, Figueras M; RITMO Group. Balboa A, et al. Eur J Gastroenterol Hepatol. 2006 Dec;18(12):1271-7. doi: 10.1097/01.meg.0000243870.41207.2f. Eur J Gastroenterol Hepatol. 2006. PMID: 17099375 - Prevalence, bowel habit subtypes and medical care-seeking behaviour of patients with irritable bowel syndrome in Northern Greece.
Katsinelos P, Lazaraki G, Kountouras J, Paroutoglou G, Oikonomidou I, Mimidis K, Koutras C, Gelas G, Tziomalos K, Zavos C, Pilpilidis I, Chatzimavroudis G. Katsinelos P, et al. Eur J Gastroenterol Hepatol. 2009 Feb;21(2):183-9. doi: 10.1097/MEG.0b013e328312eb97. Eur J Gastroenterol Hepatol. 2009. PMID: 19212207 - A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation.
Malagelada JR. Malagelada JR. Int J Clin Pract. 2006 Jan;60(1):57-63. doi: 10.1111/j.1368-5031.2005.00744.x. Int J Clin Pract. 2006. PMID: 16409429 Review. - Definition and classification of irritable bowel syndrome: current consensus and controversies.
Longstreth GF. Longstreth GF. Gastroenterol Clin North Am. 2005 Jun;34(2):173-87. doi: 10.1016/j.gtc.2005.02.011. Gastroenterol Clin North Am. 2005. PMID: 15862928 Review.
Cited by
- Downregulated APOD and FCGR2A correlates with immune infiltration and lipid-induced symptoms of irritable bowel syndrome.
Ran Y, Wu K, Hu C, Liang R, Zhang L, Xiao J, Peng Y, Sun W. Ran Y, et al. Sci Rep. 2023 Aug 30;13(1):14211. doi: 10.1038/s41598-023-41004-9. Sci Rep. 2023. PMID: 37648784 Free PMC article. - A postbiotic fermented oat gruel may have a beneficial effect on the colonic mucosal barrier in patients with irritable bowel syndrome.
Bednarska O, Biskou O, Israelsen H, Winberg ME, Walter S, Keita ÅV. Bednarska O, et al. Front Nutr. 2022 Dec 8;9:1004084. doi: 10.3389/fnut.2022.1004084. eCollection 2022. Front Nutr. 2022. PMID: 36570171 Free PMC article. - An evaluation of dietary adequacy among patients with constipation-predominant irritable bowel syndrome in Malaysia.
Shafiee NH, Razalli NH, Mokhtar NM, Tan E, Ali RAR. Shafiee NH, et al. Intest Res. 2022 Jan;20(1):124-133. doi: 10.5217/ir.2020.00050. Epub 2021 Jan 22. Intest Res. 2022. PMID: 33472341 Free PMC article. - Stool frequency and form and gastrointestinal symptoms differ by day of the menstrual cycle in healthy adult women taking oral contraceptives: a prospective observational study.
Judkins TC, Dennis-Wall JC, Sims SM, Colee J, Langkamp-Henken B. Judkins TC, et al. BMC Womens Health. 2020 Jun 29;20(1):136. doi: 10.1186/s12905-020-01000-x. BMC Womens Health. 2020. PMID: 32600463 Free PMC article. - Treatment of irritable bowel syndrome with diarrhoea using titrated ondansetron (TRITON): study protocol for a randomised controlled trial.
Gunn D, Fried R, Lalani R, Farrin A, Holloway I, Morris T, Olivier C, Kearns R, Corsetti M, Scott M, Farmer A, Emmanuel A, Whorwell P, Yiannakou Y, Sanders D, Mclaughlin J, Kapur K, Eugenicos M, Akbar A, Trudgill N, Houghton L, Dinning PG, Ford AC, Aziz Q, Spiller R. Gunn D, et al. Trials. 2019 Aug 20;20(1):517. doi: 10.1186/s13063-019-3562-6. Trials. 2019. PMID: 31429811 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical