Self-renewal and cancer of the gut: two sides of a coin - PubMed (original) (raw)
Review
. 2005 Mar 25;307(5717):1904-9.
doi: 10.1126/science.1104815.
Affiliations
- PMID: 15790842
- DOI: 10.1126/science.1104815
Review
Self-renewal and cancer of the gut: two sides of a coin
Freddy Radtke et al. Science. 2005.
Abstract
The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control homeostatic self-renewal and those that underlie colorectal cancer are remarkably symmetrical. Here, we discuss the biology of the intestinal epithelium, emphasizing the roles played by Wnt, bone morphogenic protein, and Notch signaling cascades in epithelial self-renewal and cancer.
Similar articles
- Wnt signaling in the intestinal epithelium: from endoderm to cancer.
Gregorieff A, Clevers H. Gregorieff A, et al. Genes Dev. 2005 Apr 15;19(8):877-90. doi: 10.1101/gad.1295405. Genes Dev. 2005. PMID: 15833914 Review. - Wnt control of stem cells and differentiation in the intestinal epithelium.
Pinto D, Clevers H. Pinto D, et al. Exp Cell Res. 2005 Jun 10;306(2):357-63. doi: 10.1016/j.yexcr.2005.02.022. Epub 2005 Apr 7. Exp Cell Res. 2005. PMID: 15925592 Review. - Inhibition of apoptosis during development of colorectal cancer.
Bedi A, Pasricha PJ, Akhtar AJ, Barber JP, Bedi GC, Giardiello FM, Zehnbauer BA, Hamilton SR, Jones RJ. Bedi A, et al. Cancer Res. 1995 May 1;55(9):1811-6. Cancer Res. 1995. PMID: 7728743 - [Colorectal carcinogenesis: update].
Lièvre A, Laurent-Puig P. Lièvre A, et al. Rev Prat. 2004 Jan 31;54(2):143-50. Rev Prat. 2004. PMID: 15086056 Review. French. - Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Duncan AW, et al. Nat Immunol. 2005 Mar;6(3):314-22. doi: 10.1038/ni1164. Epub 2005 Jan 23. Nat Immunol. 2005. PMID: 15665828
Cited by
- Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism.
Sun L, Dong H, Zhang Z, Liu J, Hu Y, Ni Y, Grossmann R, Zhao R. Sun L, et al. Oncotarget. 2016 May 10;7(19):27627-40. doi: 10.18632/oncotarget.8490. Oncotarget. 2016. PMID: 27050279 Free PMC article. - Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer.
Emam O, Wasfey EF, Hamdy NM. Emam O, et al. Cancer Cell Int. 2022 Oct 13;22(1):316. doi: 10.1186/s12935-022-02736-2. Cancer Cell Int. 2022. PMID: 36229883 Free PMC article. Review. - Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.
Jung B, Staudacher JJ, Beauchamp D. Jung B, et al. Gastroenterology. 2017 Jan;152(1):36-52. doi: 10.1053/j.gastro.2016.10.015. Epub 2016 Oct 20. Gastroenterology. 2017. PMID: 27773809 Free PMC article. Review. - DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.
Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang Y. Png CW, et al. Oncogene. 2016 Jan 14;35(2):206-17. doi: 10.1038/onc.2015.74. Epub 2015 Mar 16. Oncogene. 2016. PMID: 25772234 - Pro-inflammatory cytokine interleukin-1β promotes the development of intestinal stem cells.
Wang L, Liu Z, Li Y, Pappan L, Galliher-Beckley A, Shi J. Wang L, et al. Inflamm Res. 2012 Oct;61(10):1085-92. doi: 10.1007/s00011-012-0501-3. Epub 2012 Jun 16. Inflamm Res. 2012. PMID: 22706317
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical