Epidemiology and reporting of randomised trials published in PubMed journals - PubMed (original) (raw)
Epidemiology and reporting of randomised trials published in PubMed journals
An-Wen Chan et al. Lancet. 2005.
Abstract
Although randomised trials are important for evidence-based medicine, little is known about their overall characteristics. We assessed the epidemiology and reporting of methodological details for all 519 PubMed-indexed randomised trials published in December, 2000 (383 [74%] parallel-group, 116 [22%] crossover). 482 (93%) were published in specialty journals. A median of 80 participants (10th-90th percentile 25-369) were recruited for parallel-group trials. 309 (60%) were blinded. Power calculation, primary outcomes, random sequence generation, allocation concealment, and handling of attrition were each adequately described in less than half of publications. The small sample sizes are worrying, and poor reporting of methodological characteristics will prevent reliable quality assessment of many published trials.
Similar articles
- The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed.
Hopewell S, Dutton S, Yu LM, Chan AW, Altman DG. Hopewell S, et al. BMJ. 2010 Mar 23;340:c723. doi: 10.1136/bmj.c723. BMJ. 2010. PMID: 20332510 Free PMC article. - Secular changes in the quality of published randomized clinical trials in rheumatology.
Hill CL, LaValley MP, Felson DT. Hill CL, et al. Arthritis Rheum. 2002 Mar;46(3):779-84. doi: 10.1002/art.512. Arthritis Rheum. 2002. PMID: 11920415 - Poor reporting quality of key Randomization and Allocation Concealment details is still prevalent among published RCTs in 2011: a review.
Clark L, Schmidt U, Tharmanathan P, Adamson J, Hewitt C, Torgerson D. Clark L, et al. J Eval Clin Pract. 2013 Aug;19(4):703-7. doi: 10.1111/jep.12031. Epub 2013 May 7. J Eval Clin Pract. 2013. PMID: 23648066 Review. - An assessment of quality characteristics of randomised control trials published in dental journals.
Pandis N, Polychronopoulou A, Eliades T. Pandis N, et al. J Dent. 2010 Sep;38(9):713-21. doi: 10.1016/j.jdent.2010.05.014. Epub 2010 Jun 9. J Dent. 2010. PMID: 20546823 - Allocation concealment: a methodological review.
Clark L, Schmidt U, Tharmanathan P, Adamson J, Hewitt C, Torgerson D. Clark L, et al. J Eval Clin Pract. 2013 Aug;19(4):708-12. doi: 10.1111/jep.12032. Epub 2013 May 7. J Eval Clin Pract. 2013. PMID: 23648092 Review.
Cited by
- Estimating the replicability of highly cited clinical research (2004-2018).
da Costa GG, Neves K, Amaral O. da Costa GG, et al. PLoS One. 2024 Aug 7;19(8):e0307145. doi: 10.1371/journal.pone.0307145. eCollection 2024. PLoS One. 2024. PMID: 39110675 Free PMC article. - Evidence-based interventions for identifying candidate quality indicators to assess quality of care in diabetic foot clinics: a scoping review.
Lusendi FM, Vanherwegen AS, Doggen K, Nobels F, Matricali GA. Lusendi FM, et al. BMC Public Health. 2024 Apr 10;24(1):996. doi: 10.1186/s12889-024-18306-2. BMC Public Health. 2024. PMID: 38600498 Free PMC article. Review. - Primary outcome reporting in clinical trials for older adults with depression.
Rodrigues M, Oprea A, Johnson K, Dufort A, Sanger N, Ghiassi P, Sanger S, Panesar B, D'Elia A, Parpia S, Samaan Z, Thabane L. Rodrigues M, et al. BJPsych Open. 2024 Mar 7;10(2):e60. doi: 10.1192/bjo.2023.650. BJPsych Open. 2024. PMID: 38450491 Free PMC article. Review. - Guidelines for reporting pediatric and child health clinical trial protocols and reports: study protocol for SPIRIT-Children and CONSORT-Children.
Baba A, Smith M, Potter BK, Chan AW, Moher D, Offringa M. Baba A, et al. Trials. 2024 Jan 30;25(1):96. doi: 10.1186/s13063-024-07948-7. Trials. 2024. PMID: 38287439 Free PMC article. - Assessment of reporting quality of randomized controlled trials investigating the effects of inulin-type fructans supplementation on cardiovascular disease risk factors: A systematic survey.
Talukdar JR, Chu A, Garg A, Chowdhury F, E Harnack H, Huang L, Sikorski C, Mbuagbaw L, de Souza RJ. Talukdar JR, et al. PLoS One. 2024 Jan 2;19(1):e0292184. doi: 10.1371/journal.pone.0292184. eCollection 2024. PLoS One. 2024. PMID: 38166017 Free PMC article.