PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation - PubMed (original) (raw)
. 2005 Apr 1;308(5718):114-8.
doi: 10.1126/science.1107107.
Affiliations
- PMID: 15802604
- DOI: 10.1126/science.1107107
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
Ki-Young Lee et al. Science. 2005.
Abstract
Activation of the transcription factor NF-kappaB after engagement of the T cell receptor (TCR) is important for T cell proliferation and activation during the adaptive immune response. Recent reports have elucidated a signaling pathway that involves the protein kinase C (PKC), the scaffold protein CARD11 (also called CARMA-1), the caspase recruitment domain (CARD)-containing protein Bcl10, and the paracaspase (protease related to caspases) MALT1 as critical intermediates linking the TCR to the IkappaB kinase (IKK) complex. However, the events proximal to the TCR that initiate the activation of this signaling pathway remain poorly defined. We demonstrate that 3-phosphoinositide-dependent kinase 1 (PDK1) has an essential role in this pathway by regulating the activation of PKC and through signal-dependent recruiting of both PKC and CARD11 to lipid rafts. PDK1-associated PKC recruits the IKK complex, whereas PDK1-associated CARD11 recruits the Bcl10-MALT1 complex, thereby allowing activation of the IKK complex through Bcl10-MALT1-dependent ubiquitination of the IKK complex subunit known as NEMO (NF-kappaB essential modifier). Hence, PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells.
Comment in
- Cell biology. Kinasing and clipping down the NF-kappa B trail.
van Oers NS, Chen ZJ. van Oers NS, et al. Science. 2005 Apr 1;308(5718):65-6. doi: 10.1126/science.1110902. Science. 2005. PMID: 15802594 No abstract available. - Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation".
Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G. Gruber T, et al. Science. 2006 Apr 7;312(5770):55; author reply 55. doi: 10.1126/science.1115362. Science. 2006. PMID: 16601177
Similar articles
- Cell biology. Kinasing and clipping down the NF-kappa B trail.
van Oers NS, Chen ZJ. van Oers NS, et al. Science. 2005 Apr 1;308(5718):65-6. doi: 10.1126/science.1110902. Science. 2005. PMID: 15802594 No abstract available. - Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
Yang YK, Yang C, Chan W, Wang Z, Deibel KE, Pomerantz JL. Yang YK, et al. J Biol Chem. 2016 Dec 9;291(50):25921-25936. doi: 10.1074/jbc.M116.754028. Epub 2016 Oct 24. J Biol Chem. 2016. PMID: 27777308 Free PMC article. - Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.
Bidère N, Snow AL, Sakai K, Zheng L, Lenardo MJ. Bidère N, et al. Curr Biol. 2006 Aug 22;16(16):1666-71. doi: 10.1016/j.cub.2006.06.062. Curr Biol. 2006. PMID: 16920630 - NF-kappaB signaling in lymphocytes: a new cast of characters.
Lucas PC, McAllister-Lucas LM, Nunez G. Lucas PC, et al. J Cell Sci. 2004 Jan 1;117(Pt 1):31-9. doi: 10.1242/jcs.00904. J Cell Sci. 2004. PMID: 14657271 Review. - Determining the destiny of NF-kappa B after TCR ligation: it's CARMA1.
Bunnell SC. Bunnell SC. Mol Interv. 2002 Oct;2(6):356-60, 338. doi: 10.1124/mi.2.6.356. Mol Interv. 2002. PMID: 14993411 Review.
Cited by
- Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy.
Yao Z, Zeng Y, Liu C, Jin H, Wang H, Zhang Y, Ding C, Chen G, Wu D. Yao Z, et al. J Exp Clin Cancer Res. 2024 Sep 28;43(1):266. doi: 10.1186/s13046-024-03195-5. J Exp Clin Cancer Res. 2024. PMID: 39342365 Free PMC article. Review. - iTRAQ-Based Phosphoproteomic Analysis Exposes Molecular Changes in the Small Intestinal Epithelia of Cats after Toxoplasma gondii Infection.
Zhai B, Meng YM, Xie SC, Peng JJ, Liu Y, Qiu Y, Wang L, Zhang J, He JJ. Zhai B, et al. Animals (Basel). 2023 Nov 16;13(22):3537. doi: 10.3390/ani13223537. Animals (Basel). 2023. PMID: 38003154 Free PMC article. - 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib.
Meraz IM, Majidi M, Fang B, Meng F, Gao L, Shao R, Song R, Li F, Lissanu Y, Chen H, Ha MJ, Wang Q, Wang J, Shpall E, Jung SY, Haderk F, Gui P, Riess JW, Olivas V, Bivona TG, Roth JA. Meraz IM, et al. Commun Biol. 2023 May 11;6(1):509. doi: 10.1038/s42003-023-04889-w. Commun Biol. 2023. PMID: 37169941 Free PMC article. - NFκB signaling in T cell memory.
Daniels MA, Luera D, Teixeiro E. Daniels MA, et al. Front Immunol. 2023 Feb 24;14:1129191. doi: 10.3389/fimmu.2023.1129191. eCollection 2023. Front Immunol. 2023. PMID: 36911729 Free PMC article. Review. - A single-cell analysis of thymopoiesis and thymic iNKT cell development in pigs.
Gu W, Madrid DMC, Joyce S, Driver JP. Gu W, et al. Cell Rep. 2022 Jul 5;40(1):111050. doi: 10.1016/j.celrep.2022.111050. Cell Rep. 2022. PMID: 35793622 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous