Communicating with Hedgehogs - PubMed (original) (raw)

Review

doi: 10.1038/nrm1622.

Affiliations

Review

Communicating with Hedgehogs

Joan E Hooper et al. Nat Rev Mol Cell Biol. 2005 Apr.

Abstract

Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources