Cortical inhibitory neurons and schizophrenia - PubMed (original) (raw)
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doi: 10.1038/nrn1648.
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- PMID: 15803162
- DOI: 10.1038/nrn1648
Review
Cortical inhibitory neurons and schizophrenia
David A Lewis et al. Nat Rev Neurosci. 2005 Apr.
Abstract
Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.
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