Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders - PubMed (original) (raw)
. 2005 May 5;135B(1):85-93.
doi: 10.1002/ajmg.b.30177.
Michael R Lowry, R Lynn Richards, Agnes M Plenk, Catherine Carter, Charles H Hensel, Victor Abkevich, Mark H Skolnick, Donna Shattuck, Kerry G Rowe, Dana C Hughes, Lisa A Cannon-Albright
Affiliations
- PMID: 15806581
- DOI: 10.1002/ajmg.b.30177
Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders
Nicola J Camp et al. Am J Med Genet B Neuropsychiatr Genet. 2005.
Abstract
Major depressive disorder (MDD) is a common, clinically heterogeneous disorder often found comorbid with other disorders. We studied recurrent, early-onset MDD (MDD-RE) and anxiety disorders in combination to define powerful phenotypes for genetic study. We used 87 large, extended Utah pedigrees to investigate linkage to 3 phenotypes: "MDD-RE;" "MDD-RE or anxiety;" and "MDD-RE and anxiety;" where in the latter definition the disorders must appear comorbid within an individual. Pedigrees ranged in size from 2 to 6 generations and contained 3 to 42 individuals affected with MDD or anxiety (718 total). In primary analyses, we identified three regions with at least suggestive genome-wide evidence for linkage on chromosomes 3centr, 7p, and 18q. Both 7p and 18q are replication findings for related phenotypes. The best linkage evidence was for a novel locus at 3p12.3-q12.3 (LOD = 3.88, "MDD-RE or anxiety") and 18q21.33-q22.2 (LOD = 3.75, "MDD-RE and anxiety"), a well-established susceptibility locus for bipolar disorder. In our secondary sex-specific analyses, we identified two further regions of interest on chromosomes 4q and 15q. Using linked pedigrees, we localized 3centr and 18q to 9.8 and 12.2 cM, respectively, with potential for further localization with the addition of markers in specific pedigrees. Our success in replication and novel locus identification illustrates the utility of large extended pedigrees for common disorders, such as MDD. Further, it supports the hypothesis that MDD and anxiety disorders have over-lapping genetic etiologies and suggests that comorbid diagnoses may be useful in defining more genetically homogeneous forms of MDD for linkage mapping.
Copyright 2005 Wiley-Liss, Inc.
Similar articles
- Linkage genome scan for loci predisposing to panic disorder or agoraphobia.
Gelernter J, Bonvicini K, Page G, Woods SW, Goddard AW, Kruger S, Pauls DL, Goodson S. Gelernter J, et al. Am J Med Genet. 2001 Aug 8;105(6):548-57. doi: 10.1002/ajmg.1496. Am J Med Genet. 2001. PMID: 11496373 - Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression.
Zubenko GS, Maher BS, Hughes HB 3rd, Zubenko WN, Scott Stiffler J, Marazita ML. Zubenko GS, et al. Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):47-54. doi: 10.1002/ajmg.b.30092. Am J Med Genet B Neuropsychiatr Genet. 2004. PMID: 15274040 - Genome-wide linkage analysis for aggressive prostate cancer in Utah high-risk pedigrees.
Christensen GB, Camp NJ, Farnham JM, Cannon-Albright LA. Christensen GB, et al. Prostate. 2007 May 1;67(6):605-13. doi: 10.1002/pros.20554. Prostate. 2007. PMID: 17299800 - Meta-analysis of genome-wide linkage studies of asthma and related traits.
Denham S, Koppelman GH, Blakey J, Wjst M, Ferreira MA, Hall IP, Sayers I. Denham S, et al. Respir Res. 2008 Apr 28;9(1):38. doi: 10.1186/1465-9921-9-38. Respir Res. 2008. PMID: 18442398 Free PMC article. Review. - The genetics of depression and related traits.
Huezo-Diaz P, Tandon K, Aitchison KJ. Huezo-Diaz P, et al. Curr Psychiatry Rep. 2005 Apr;7(2):117-24. doi: 10.1007/s11920-005-0008-5. Curr Psychiatry Rep. 2005. PMID: 15802088 Review.
Cited by
- Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.
Teerlink CC, Camp NJ, Bansal A, Crapo R, Hughes D, Kort E, Rowe K, Cannon-Albright LA. Teerlink CC, et al. Eur J Hum Genet. 2009 May;17(5):636-43. doi: 10.1038/ejhg.2008.236. Epub 2008 Dec 17. Eur J Hum Genet. 2009. PMID: 19092775 Free PMC article. - Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.
Amin N, Jovanova O, Adams HH, Dehghan A, Kavousi M, Vernooij MW, Peeters RP, de Vrij FM, van der Lee SJ, van Rooij JG, van Leeuwen EM, Chaker L, Demirkan A, Hofman A, Brouwer RW, Kraaij R, Willems van Dijk K, Hankemeier T, van Ijcken WF, Uitterlinden AG, Niessen WJ, Franco OH, Kushner SA, Ikram MA, Tiemeier H, van Duijn CM. Amin N, et al. Mol Psychiatry. 2017 Apr;22(4):537-543. doi: 10.1038/mp.2016.101. Epub 2016 Jul 19. Mol Psychiatry. 2017. PMID: 27431295 - Genome-wide linkage scans for major depression in individuals with alcohol dependence.
Kuo PH, Neale MC, Walsh D, Patterson DG, Riley B, Prescott CA, Kendler KS. Kuo PH, et al. J Psychiatr Res. 2010 Jul;44(9):616-9. doi: 10.1016/j.jpsychires.2009.12.005. Epub 2010 Jan 13. J Psychiatr Res. 2010. PMID: 20074746 Free PMC article. - PDLIM5 gene polymorphisms and short term antidepressant response in Chinese major depressive disorders.
Liu Z, Zhu F, Yao L, Yang C, Xiao L, Zhu J, Wang H, Wang G, Liu W, Xiao Z. Liu Z, et al. Int J Clin Exp Med. 2013 Sep 1;6(8):677-82. eCollection 2013. Int J Clin Exp Med. 2013. PMID: 24040476 Free PMC article. - Genetics Factors in Major Depression Disease.
Shadrina M, Bondarenko EA, Slominsky PA. Shadrina M, et al. Front Psychiatry. 2018 Jul 23;9:334. doi: 10.3389/fpsyt.2018.00334. eCollection 2018. Front Psychiatry. 2018. PMID: 30083112 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical