A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender - PubMed (original) (raw)
A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender
R Mayeux et al. Arch Neurol. 1992 May.
Abstract
Because the prevalence of idiopathic Parkinson's disease (PD) with or without dementia remains controversial, we initiated a population-based investigation in the Washington Heights-Inwood section of New York, NY, so that nearly complete case ascertainment could be achieved. A "registry" was developed for the study, and we advertised in periodicals and on radio and television. Subjects, or their records, were examined by experienced neurologists, and most underwent a battery of neuropsychological tests specifically designed for assessment in this community. All data were reviewed by a team of clinicians to achieve a consensus diagnosis. The crude prevalence of idiopathic PD, with and without dementia, was 99.4 per 100,000, increasing from 2.3 per 100,000 for those younger than 50 years to 1144.9 per 100,000 for those aged 80 years and older. The crude prevalence for PD with dementia alone was 41.1 per 100,000 and also increased with age from zero for those younger than 50 years to 787.1 per 100,000 for those aged 80 years and older. Prevalence ratios were comparable with those of other published population-based studies in similar settings. After standardization, men had PD with and without dementia more frequently than did women. The major difference between patients with and without dementia was a later estimated age at onset of motor manifestations. We conclude that PD is a frequent disorder in the elderly population that affects men and whites more frequently than women and nonwhites. Moreover, dementia in patients with PD is more frequent than previously recognized and is strongly related to the age at onset of motor manifestations.
Similar articles
- An estimate of the prevalence of dementia in idiopathic Parkinson's disease.
Mayeux R, Stern Y, Rosenstein R, Marder K, Hauser A, Cote L, Fahn S. Mayeux R, et al. Arch Neurol. 1988 Mar;45(3):260-2. doi: 10.1001/archneur.1988.00520270034017. Arch Neurol. 1988. PMID: 3341950 - Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom.
Hobson P, Meara J. Hobson P, et al. Mov Disord. 2004 Sep;19(9):1043-9. doi: 10.1002/mds.20216. Mov Disord. 2004. PMID: 15372593 - Parkinson disease with and without Dementia: A prevalence study and future projections.
Savica R, Grossardt BR, Rocca WA, Bower JH. Savica R, et al. Mov Disord. 2018 Apr;33(4):537-543. doi: 10.1002/mds.27277. Epub 2018 Jan 22. Mov Disord. 2018. PMID: 29356127 Free PMC article. - The epidemiology of dementia associated with Parkinson disease.
Aarsland D, Kurz MW. Aarsland D, et al. J Neurol Sci. 2010 Feb 15;289(1-2):18-22. doi: 10.1016/j.jns.2009.08.034. Epub 2009 Sep 4. J Neurol Sci. 2010. PMID: 19733364 Review. - A systematic review of prevalence studies of dementia in Parkinson's disease.
Aarsland D, Zaccai J, Brayne C. Aarsland D, et al. Mov Disord. 2005 Oct;20(10):1255-63. doi: 10.1002/mds.20527. Mov Disord. 2005. PMID: 16041803 Review.
Cited by
- Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders.
Sánchez MG, Bourque M, Morissette M, Di Paolo T. Sánchez MG, et al. CNS Neurosci Ther. 2010 Jun;16(3):e43-71. doi: 10.1111/j.1755-5949.2010.00163.x. CNS Neurosci Ther. 2010. PMID: 20557567 Free PMC article. Review. - Untapped ethical resources for neurodegeneration research.
Robillard JM, Federico CA, Tairyan K, Ivinson AJ, Illes J. Robillard JM, et al. BMC Med Ethics. 2011 Jun 2;12:9. doi: 10.1186/1472-6939-12-9. BMC Med Ethics. 2011. PMID: 21635769 Free PMC article. - High risk of developing dementia in Parkinson's disease: a Swedish registry-based study.
Åström DO, Simonsen J, Raket LL, Sgarbi S, Hellsten J, Hagell P, Norlin JM, Kellerborg K, Martinez-Martin P, Odin P. Åström DO, et al. Sci Rep. 2022 Oct 6;12(1):16759. doi: 10.1038/s41598-022-21093-8. Sci Rep. 2022. PMID: 36202962 Free PMC article. - Enhanced striatal β1-adrenergic receptor expression following hormone loss in adulthood is programmed by both early sexual differentiation and puberty: a study of humans and rats.
Meitzen J, Perry AN, Westenbroek C, Hedges VL, Becker JB, Mermelstein PG. Meitzen J, et al. Endocrinology. 2013 May;154(5):1820-31. doi: 10.1210/en.2012-2131. Epub 2013 Mar 26. Endocrinology. 2013. PMID: 23533220 Free PMC article. - Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.
Uversky VN, Eliezer D. Uversky VN, et al. Curr Protein Pept Sci. 2009 Oct;10(5):483-99. doi: 10.2174/138920309789351921. Curr Protein Pept Sci. 2009. PMID: 19538146 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical